{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:00:42Z","timestamp":1789592442407,"version":"build-2803163510"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002655","name":"Terry Fox Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The purpose of this study was to evaluate the radiotherapy planning feasibility of dose escalation with intensity\u2010modulated proton therapy (IMPT) to hypoxic tumor regions identified on 18F\u2010Fluoromisonidazole (FMISO) positron emission tomography and computed tomography (PET\u2010CT) in NPC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Nine patients with stages T3\u20104N0\u20103M0 NPC underwent 18F\u2010FMISO PET\u2010CT before and during week 3 of radiotherapy. The hypoxic volume (GTVhypo) is automatically generated by applying a subthresholding algorithm within the gross tumor volume (GTV) with a tumor to muscle standardized uptake value (SUV) ratio of 1.3 on the 18F\u2010FMISO PET\u2010CT scan. Two proton plans were generated for each patient, a standard plan to 70\u00a0Gy and dose escalation plan with upfront boost followed by standard 70GyE plan. The stereotactic boost was planned with single\u2010field uniform dose optimization using two fields to deliver 10 GyE in two fractions to GTVhypo. The standard plan was generated with IMPT with robust optimization to deliver 70GyE, 60GyE in 33 fractions using simultaneous integrated boost technique. A plan sum was generated for assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight of nine patients showed tumor hypoxia on the baseline 18F\u2010FMISO PET\u2010CT scan. The mean hypoxic tumor volume was 3.9 cm<jats:sup>3<\/jats:sup> (range .9\u201311.9cm<jats:sup>3<\/jats:sup>). The average SUVmax of the hypoxic volume was 2.2 (range 1.44\u20132.98). All the dose\u2010volume parameters met the planning objectives for target coverage. Dose escalation was not feasible in three of eight patients as the D0.03cc of temporal lobe was greater than 75GyE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The utility of boost to the hypoxic volume before standard course of radiotherapy with IMPT is dosimetrically feasible in selected patients. Clinical trials are warranted to determine the clinical outcomes of this approach.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13953","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T05:58:16Z","timestamp":1683611896000},"page":"611-619","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["18F\u2010FMISO PET\u2010guided dose escalation with multifield optimization intensity\u2010modulated proton therapy in nasopharyngeal carcinoma"],"prefix":"10.1111","volume":"20","author":[{"given":"Kiattisa","family":"Sommat","sequence":"first","affiliation":[{"name":"Division of Radiation Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron Kian Ti","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital  Singapore 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