{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:07:52Z","timestamp":1766599672485,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T00:00:00Z","timestamp":1683504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This study aimed to analyze the clinical characteristics and outcomes of patients with primary dumbbell chordoma of the cervical spine and to summarize the causes of misdiagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinical data of patients were retrospectively collected. The diagnostic process, surgical procedures, and outcomes were analyzed, then the difference was compared between dumbbell and non\u2010dumbbell chordomas of the cervical spine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study included six patients with primary dumbbell chordoma (one male and five females) with a mean age of 32.2\u00a0\u00b1\u00a024.5\u00a0years (range: 5\u201361\u00a0years). Five cases with no computed tomography (CT) examination before the first operation were misdiagnosed, and on magnetic resonance imaging (MRI), primary dumbbell chordoma showed the following specific features: extensive invasion of the surrounding soft tissues with an obscure boundary (\u22655\u00a0cm), intervertebral disc sparing, and hemorrhagic necrosis, furthermore, the CT features included atypical destructive vertebral lesions, minimal intralesional calcification, and neural foraminal enlargement. After comparison with non\u2010dumbbell chordomas, it show statistical difference (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) in terms of calcification, foramen enlargement, FNA, misdiagnosis rate but with different recurrent rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Primary dumbbell chordomas of the cervical spine can easily be misdiagnosed as neurogenic tumors. Preoperative CT\u2010guided fine\u2010needle aspiration puncture biopsy helps make an accurate diagnosis. Gross total excision with postoperative radiotherapy has been proven effective in reducing the recurrence rate.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13968","type":"journal-article","created":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T08:23:35Z","timestamp":1683534215000},"page":"620-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Misdiagnosis of primary dumbbell chordoma of the cervical spine"],"prefix":"10.1111","volume":"20","author":[{"given":"Hua","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Orthopedics Peking University Third Hospital  Beijing China"},{"name":"Engineering Research Center of Bone and Joint Precision Medicine  Beijing China"},{"name":"Beijing Key Laboratory of Spinal Disease Research  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department 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