{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,17]],"date-time":"2024-11-17T10:10:14Z","timestamp":1731838214093,"version":"3.28.0"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Stereotactic ablative radiotherapy (SABR) for early\u2010stage lung cancer has shown promising results; however, regional recurrence (RR) development is not uncommon, and salvage treatment strategies have not been established. We aimed to investigate treatment patterns, prognostic factors, and survival outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>A retrospective analysis of 391 patients who underwent SABR for primary lung cancer from 2012 to 2019 was performed. Among these patients, 90 patients showed recurrence, including local recurrence (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), RR (<jats:italic>n<\/jats:italic>\u00a0=\u00a033), distant metastasis (DM) (<jats:italic>n<\/jats:italic>\u00a0=\u00a057), and RR with simultaneous DM (<jats:italic>n<\/jats:italic>\u00a0=\u00a08). The median follow\u2010up duration was 17.3 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age was 75 years, and most patients underwent primary SABR due to poor lung function (69.7%). Various salvage treatments were performed in cases of RR, including chemotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), radiotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a07), concurrent chemoradiotherapy (<jats:italic>n<\/jats:italic>\u00a0=\u00a02), and best supportive care (<jats:italic>n<\/jats:italic>\u00a0=\u00a09). The median overall survival (OS) and post\u2010recurrence OS (PR\u2010OS) were 22.9 and 11.2 months, respectively. In multivariate analysis, age \u226475 years (HR\u00a0=\u00a00.36, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.040), isolated recurrence (HR\u00a0=\u00a00.34, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.037), and radiotherapy without chemotherapy (HR\u00a0=\u00a00.25, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.024) were significant prognostic factors for PR\u2010OS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite various salvage treatments, PR\u2010OS was less than 1 year after RR in our frail patients group who underwent primary SABR. The toxicities of salvage chemotherapy could be quite severe; thus, careful patient selection is required. Further research is needed to validate our findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.13992","type":"journal-article","created":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T10:13:02Z","timestamp":1688551982000},"page":"652-660","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment patterns and results of salvage treatment for regional recurrences after stereotactic ablative radiotherapy for primary non\u2010small cell lung cancer"],"prefix":"10.1111","volume":"20","author":[{"given":"Choong\u2010Won","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung Hyuck","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul Metropolitan Government Seoul National University Boramae Medical Center Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Gyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Seoul National University College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hak Jae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Seoul National University Hospital Seoul Republic of Korea"},{"name":"Department of Radiation Oncology Seoul National University College of Medicine Seoul Republic of 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