{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:08:01Z","timestamp":1790827681169,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,8,27]],"date-time":"2023-08-27T00:00:00Z","timestamp":1693094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Molecular genetics serve a critical role in constructing risk stratification for hematological malignancies, but T\u2010cell lymphoma (TCL) still lacks molecular genetic information for supplement risk stratification in predicting the prognosis of TCL patients. In the present study, we characterized the mutation patterns of B\u2010cell leukemia\/lymphoma 11B gene (<jats:italic>BCL11B<\/jats:italic>) and its prognostic importance in TCL patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p><jats:italic>BCL11B<\/jats:italic> mutations were characterized based on the data from two datasets, one is from our clinical center (GDPH dataset, <jats:italic>n<\/jats:italic>\u00a0=\u00a079) and the other is from COSMIC dataset (<jats:italic>n<\/jats:italic>\u00a0=\u00a0154).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall mutation rate of <jats:italic>BCL11B<\/jats:italic> was 6.4% (15\/233) in TCL, and there were no hotspot mutation sites in TCL. Among these mutations, the missense and splice site mutation were significantly prominent. Moreover, TCL patients harboring <jats:italic>BCL11B<\/jats:italic> mutations had a favorable overall survival (OS) in our center (GDPH dataset) (adjusted hazard ratio [HR]\u00a0=\u00a0.001, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.109), although there were not yet significantly statistical at this point. In addition, TCL patients harboring <jats:italic>BCL11B<\/jats:italic> mutation had a longer 5\u2010year restricted mean survival time (RMST) than those without a <jats:italic>BCL11B<\/jats:italic> mutation (60\u00a0vs. 32 months). Notably, <jats:italic>BCL11B<\/jats:italic> mutations were not associated with TCL entities having better prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:italic>BCL11B<\/jats:italic> mutations were associated with favorable clinical outcome for TCL patients; it might be considered as a novel biomarker for TCL prognostic stratification.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.14000","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:39:32Z","timestamp":1693204772000},"page":"81-86","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["T\u2010cell lymphoma patient harboring <i>BCL11B<\/i> mutations had favorable overall survival"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3733-9174","authenticated-orcid":false,"given":"Cunte","family":"Chen","sequence":"first","affiliation":[{"name":"Key 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