{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T23:55:59Z","timestamp":1774655759060,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T00:00:00Z","timestamp":1713052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aimed to analyze the relationship between human epididymal protein 4 (HE4) and infiltration depth, postoperative recurrence, and metastasis of epithelial ovarian cancer (OVCA). Immunohistochemistry was used to detect the expression level of HE4 in cancer tissues and adjacent tissues of 90 patients with epithelial OVCA admitted to our hospital from May 2017 to January 2018. Cox regression was used to analyze the factors affecting the prognosis of epithelial OVCA. The relationship between HE4 and the prognosis of epithelial OVCA was analyzed by the receiver operating characteristic curve and Kaplan\u2010Meier survival curve. The positive expression rate of HE4 in epithelial OVCA was 85.56%, which was higher than 34.44% in adjacent tissues (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01). The International Federation of Gynecology and Obstetrics stage, infiltration depth, lymph node metastasis, postoperative recurrence and metastasis, and HE4 positivity were independent risk factors for the prognosis, and platinum\u2010based chemotherapy sensitivity was an independent protective factor for the prognosis of patients with epithelial OVCA (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). The area under the curve of HE4 in diagnosing epithelial OVCA and predicting recurrence was 0.863 and 0.700, the sensitivity was 91.60% and 85.60%, and the specificity was 90.20% and 65.60%. The median progression\u2010free survival and overall survival were 26.1 and 30.2 months in HE4\u2010positive epithelial OVCA patients, while these were 31.4 and 35.6 months in HE4\u2010negative epithelial OVCA patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). In conclusion, HE4 was highly expressed in epithelial OVCA tissues. Its expression level was related to the depth of tumor invasion, postoperative recurrence and metastasis, and other clinicopathological characteristics of patients with epithelial OVCA.<\/jats:p>","DOI":"10.1111\/ajco.14062","type":"journal-article","created":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T14:30:25Z","timestamp":1713105025000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Relationship between human epididymal protein 4 and depth of tumor invasion, postoperative recurrence, and metastasis of epithelial epithelial ovarian cancer"],"prefix":"10.1111","author":[{"given":"Yan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Gynaecology Shanxi Maternal and Child Health Hospital  Taiyuan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxiang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Shanxi Maternal and Child Health Hospital  Taiyuan P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Panhong","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Pathology Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7005-7542","authenticated-orcid":false,"given":"Xiaohui","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Henan Provincial People's Hospital Zhengzhou University People's Hospital  Zhengzhou P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,14]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-021-11087-7"},{"issue":"2","key":"e_1_2_11_3_1","article-title":"Survival outcome after interval cytoreductive surgery in advanced\u2010stage epithelial ovarian carcinoma: a tertiary care centre experience","volume":"19","author":"Nath AG","year":"2021","journal-title":"Indian J Gynecol Oncol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(21)00878-7"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2019.02.017"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0b013e318234f852"},{"issue":"7","key":"e_1_2_11_7_1","first-page":"159","article-title":"Role of carbohydrate antigen 125 combined with human epididymal secretory protein 4 in the prognosis of patients with OVCA","volume":"26","author":"Yang N","year":"2019","journal-title":"China Mod Med"},{"issue":"3","key":"e_1_2_11_8_1","first-page":"159","article-title":"Clinical value of serum carbohydrate antigen 125, human epididymal secretion protein 4 and OVCA risk prediction index in the early diagnosis of OVCA","volume":"26","author":"Xu MM","year":"2019","journal-title":"China Mod Med"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01941-1"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4301247"},{"issue":"7","key":"e_1_2_11_11_1","article-title":"Neoadjuvant chemotherapy before surgery versus surgery followed by chemotherapy for initial treatment in advanced ovarian epithelial cancer","volume":"7","author":"Coleridge SL","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2020.1835844"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/6959637"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3233\/CBM-160529"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-021-00845-6"},{"issue":"14","key":"e_1_2_11_16_1","first-page":"1759","article-title":"Levels of CA125 and HE4 in patients with epithelial OVCA and their clinical significance","volume":"40","author":"Shuli MA","year":"2019","journal-title":"Int J Lab Med"},{"issue":"22","key":"e_1_2_11_17_1","first-page":"2767","article-title":"The relationship between serum HE4 and disease progression stage in patients with CKD after renal transplantation and its diagnostic value","volume":"40","author":"Bai B","year":"2019","journal-title":"Int J Lab Med"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2020.5147"},{"issue":"5","key":"e_1_2_11_19_1","first-page":"XC01","article-title":"Serum HE4 detects OVCA recurrence earlier than CA 125: Indian study","volume":"12","author":"Akhtar N","year":"2018","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-020-00759-9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05681-5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450118666170404154929"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.14062","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,14]],"date-time":"2024-04-14T14:30:31Z","timestamp":1713105031000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.14062"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,14]]},"references-count":21,"alternative-id":["10.1111\/ajco.14062"],"URL":"https:\/\/doi.org\/10.1111\/ajco.14062","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,14]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ajco.14062"}}