{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:25:43Z","timestamp":1753878343483,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We evaluated the efficacy of neoadjuvant chemotherapy with intensity\u2010modulated radiotherapy (NAC\u2010IMRT) in patients with borderline\u2010resectable pancreatic cancer (BRPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>BRPC patients were treated with IMRT (45\u00a0Gy\/15fr) combined with two courses of S\u20101 (40\u00a0mg\/m<jats:sup>2<\/jats:sup> bid) before surgery. Outcomes after NAC\u2010IMRT, surgery, and survival were then evaluated. This single\u2010center retrospective study assessed 26 consecutive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six patients (BR\u2010PV: 7, BR\u2010A: 19) with a median age of 73 years were enrolled from 2016 to 2021. Ten (38%) patients were 75\u2010years\u2010old and above. Twenty\u2010three patients completed NAC\u2010IMRT treatment. The median reductions in tumor size and cancer antigen 19\u20109 level were 13.6% and 69%, respectively. All 26 patients underwent resection within a median time of 71 days after NAC\u2010IMRT initiation. R0 resection was achieved in 24 patients (92%). The median overall survival (OS) was 28.0 months, and the 1\u2010 and 3\u2010year OS rates were 100% and 34%, respectively. The median progression\u2010free survival (PFS) was 12.5 months, and the 1\u2010 and 3\u2010year PFS rates were 50% and 32%, respectively. No significant differences were observed in OS between the patients under and over the age of 75 (29\u00a0vs. 20 months, <jats:italic>p<\/jats:italic>\u00a0=\u00a00.86). The 12 patients who completed NAC\u2010IMRT, resection, and subsequent adjuvant chemotherapy (AC) exhibited a 3\u2010year survival rate of 73%, which was significantly better than that of the patients who did not receive or complete AC (median OS, not reached vs. 19 months, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NAC\u2010IMRT showed outstanding clinical efficacy with acceptable tolerability in patients with BRPC, including geriatric patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajco.14080","type":"journal-article","created":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T15:10:01Z","timestamp":1716304201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neoadjuvant therapy with intensity\u2010modulated radiotherapy combined with S\u20101 for borderline\u2010resectable pancreatic 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