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Pivotal systemic therapy trials utilize conventionally fractionated chemoradiation at 2\u00a0Gy per fraction given over 6\u00a0weeks. In practice, 4\u00a0weeks of chemoradiation at 2.75\u00a0Gy per fraction is sometimes employed to reduce the treatment burden for selected patients, especially those who are older or have comorbidities. It is uncertain if the two fractionation regimens are similar in biological effectiveness, especially with varying systemic therapy. This systematic review aimed to collate the survival and toxicity outcomes for 4\u00a0weeks of moderately hypofractionated chemoradiation, using &gt;\u00a050\u00a0\u201360\u00a0Gy in 20 fractions. Eight studies met the eligibility criteria; seven studies were from a database search of MEDLINE, EMBASE, Cochrane Library, and Web of Science and one study was added later. Two studies were prospective randomized trials and six were retrospective cohort studies. No study included immunotherapy. The historical evidence has been limited, but emerging data is promising, especially when compared to outcomes of standard chemoradiation. Thus, further investigation of this strategy is justified.<\/jats:p>","DOI":"10.1111\/ajco.14152","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:49:34Z","timestamp":1738198174000},"page":"359-367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Safety of Four Weeks of Moderately Hypofractionated Chemoradiation for Unresectable, Stage 3 Non\u2013Small Cell Lung Cancer: A Systematic Review"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9909-3945","authenticated-orcid":false,"given":"Joanna Jane","family":"Ludbrook","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Calvary Mater Newcastle  Waratah New South Wales Australia"},{"name":"School of Medicine and Public Health University of Newcastle  Callaghan New South Wales 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