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One hundred seventy\u2010three patients were enrolled. Seventy\u2010eight cases were treated with type I and proved to be microinvasion cancer. Of them, 21 willingly selected followed up and 57 were further undergone type II. Ninety\u2010five underwent type III and confirmed to be superficial invasion cancer in which Reinke's space was invaded. Five(23.8%), four(7.0%) and nine (9.5%)cases separately relapsed in type I, II and III. No significant difference was observed (<jats:italic>p<\/jats:italic>&gt;0.05). 5\/60, 5\/11 and 8\/102 patients respectively replaced in negative, positive and uncertain margin groups. There were remarkable differences among them (<jats:italic>p<\/jats:italic>&lt;0.05). The recurrence rate is still low for patients with early glottic cancer undergone vocal cord resection using CO<jats:sub>2<\/jats:sub> laser, and the appropriate surgical method should be selected for a diverse range of glottic cancer to avoid overtreatment. Patients with positive incisal margins have a relatively high recurrence rate and should take this situation seriously.<\/jats:p>","DOI":"10.1111\/ajco.14155","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T16:36:54Z","timestamp":1739205414000},"page":"552-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management Experience of T1 Glottic Cancer Treated by CO<sub>2<\/sub> Laser Surgery: A Cohort of 173 Patients"],"prefix":"10.1111","volume":"21","author":[{"given":"Changjiang","family":"Li","sequence":"first","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology (Shanghai Key Clinical Disciplines of Otorhinolaryngology) Eye &amp; ENT Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Chen","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology (Shanghai Key Clinical Disciplines of Otorhinolaryngology) Eye &amp; ENT Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peijie","family":"He","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology (Shanghai Key Clinical Disciplines of Otorhinolaryngology) Eye &amp; ENT Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Cheng","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology (Shanghai Key Clinical Disciplines of Otorhinolaryngology) Eye &amp; ENT Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7617-2832","authenticated-orcid":false,"given":"Haitao","family":"Wu","sequence":"additional","affiliation":[{"name":"ENT Institute and Department of Otorhinolaryngology (Shanghai Key Clinical Disciplines of Otorhinolaryngology) Eye &amp; ENT Hospital, Fudan University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,2,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947208100606"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"issue":"1","key":"e_1_2_11_4_1","first-page":"E712","article-title":"Relationship Between CO2 Laser\u2010induced Artifact and Glottic Cancer Surgical Margins at Variable Power Doses","volume":"38","author":"Buchanan M. 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