{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:43:22Z","timestamp":1762202602092,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>Invasive lobular carcinoma (ILC) is the second most common breast cancer type after invasive ductal carcinoma (IDC). Eribulin mesylate (eribulin) is a non\u2010taxane microtubule dynamics inhibitor approved for advanced or metastatic breast cancer, including ILC and IDC. However, real\u2010world data from eribulin\u2010treated patients with advanced or metastatic ILC are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This post hoc analysis of a Japanese multicenter, prospective, observational post\u2010marketing surveillance (ClinicalTrials.gov: NCT02371174) evaluated data from eribulin\u2010treated patients with ILC or IDC. Overall survival (OS) from the initiation of first\u2010line chemotherapy, OS from the first date of eribulin administration, and time\u2010to\u2010treatment failure (TTF) were evaluated. OS from eribulin initiation was also evaluated by line of eribulin treatment (first\u2010line, second\u2010line, and third\u2010line or later). Adverse drug reactions (ADRs) with \u2265 5% frequency in both groups were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among patients with ILC (\n                      <jats:italic>n<\/jats:italic>\n                      = 33) and IDC (\n                      <jats:italic>n<\/jats:italic>\n                      = 543), median OS from the initiation of first\u2010line chemotherapy was 25.5 and 39.0 months, respectively (hazard ratio 1.94 [95% confidence interval 1.28\u20132.94];\n                      <jats:italic>p<\/jats:italic>\n                      &lt; 0.05), median OS from the first date of eribulin administration was 16.0 and 18.0 months, respectively (1.31 [0.87\u20131.97]), and TTF was 6 and 5 months (0.92 [0.65\u20131.32]). No significant differences were observed in median OS when stratified by line of eribulin treatment. Type and frequency of ADRs did not differ significantly between the groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>OS and TTF after eribulin initiation were similar between ILC and IDC cases, suggesting that eribulin might be a beneficial treatment option for ILC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.14189","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T22:53:53Z","timestamp":1747954433000},"page":"623-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prognosis of Invasive Lobular Carcinoma and Effectiveness of Eribulin in Clinical Practice: A Post Hoc Analysis of a 2\u2010Year Post\u2010Marketing Surveillance"],"prefix":"10.1111","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9279-5952","authenticated-orcid":false,"given":"Yuko","family":"Tanabe","sequence":"first","affiliation":[{"name":"Medical Oncology Toranomon Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenichi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Breast Care Saitama Medical Center  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Hokkaido University Hospital  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirofumi","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology National Cancer Center Hospital East  Kashiwa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery and Oncology Kanagawa Cancer Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiyomi","family":"Egawa","sequence":"additional","affiliation":[{"name":"JUN Ladies Clinic  Amagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohei","family":"Uchida","sequence":"additional","affiliation":[{"name":"Eisai Co., Ltd  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Higashibeppu","sequence":"additional","affiliation":[{"name":"Eisai Co., Ltd  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukinori","family":"Sakata","sequence":"additional","affiliation":[{"name":"Eisai Co., Ltd  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michiko","family":"Sugawara","sequence":"additional","affiliation":[{"name":"Eisai Co., Ltd  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Tsurutani","sequence":"additional","affiliation":[{"name":"Advanced Cancer Translational Research Institute Showa Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010015\u20100519\u2010x"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13058\u2010020\u201001384\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010022\u201006572\u2010w"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2012.557"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010019\u201005234\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2021.07.011"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2021.12.036"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(11)60070\u20106"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010014\u20102923\u20109"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064\u2010015\u20101322\u2010y"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064\u2010016\u20101833\u20101"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2016.12.017"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104628\u20107"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282\u2010017\u20100826\u20104"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010018\u20104556\u20106"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010017\u20100486\u20104"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010018\u20103567\u2010y"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2018\u20100182"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10637\u2010019\u201000890\u20105"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282\u2010018\u20100919\u20108"},{"volume-title":"WHO Classification of Breast Tumours","year":"2019","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_11_22_1"},{"volume-title":"Breast Cancer Treatment Regulations","year":"2018","author":"The Japanese","key":"e_1_2_11_23_1"},{"key":"e_1_2_11_24_1","unstructured":"R.Core Team \u201cR: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing \u201d2025 https:\/\/www.R\u2010project.org\/."},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552\u2010018\u20101121\u20101"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8838"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13153695"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/onco.13734"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12282\u2010017\u20100753\u20104"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.80"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2016.122"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201014\u20103252"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.14189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T20:31:28Z","timestamp":1762201888000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.14189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/ajco.14189"],"URL":"https:\/\/doi.org\/10.1111\/ajco.14189","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"type":"print","value":"1743-7555"},{"type":"electronic","value":"1743-7563"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"assertion":[{"value":"2024-05-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}