{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T07:02:57Z","timestamp":1792825377914,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n This study aimed to investigate the prognostic significance of inflammatory indices, including the advanced lung inflammation index (ALI), in extensive\u2010stage small cell lung cancer (ES\u2010SCLC) patients receiving first\u2010line platinum\u2010etoposide chemotherapy.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The study included 167 ES\u2010SCLC patients. Patients with confirmed ES\u2010SCLC histology who had completed at least 2\u00a0months of first\u2010line treatment (platinum etoposide chemotherapy regimen without immunotherapy) were included. Demographic information, clinicopathological characteristics, and blood parameters (blood test results between Days 1 and 7 before the first chemotherapy) of the patients before the first treatment were recorded from the electronic record system.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Median age was 62\u00a0years (range: 40\u201388\u00a0years). A total of 163 (97.6%) patients had died of cancer\u2010related causes. For all patients, the median OS (mOS) was 9 (95% CI: 8\u201310)\u00a0months. In univariate analysis, gender, age, smoking, BMI, brain metastasis status, bone metastasis status, PCI (prophylactic cranial irradiation), and SVCSS (superior vena cava syndrome) were not associated with survival. Poor performance status (\n p<\/jats:italic>\n = 0.036), low C\u2010reactive protein\u2010albumin\u2010lymphocyte index (CALLY) (\n p<\/jats:italic>\n = 0.030), high systemic immune inflammation index (SII) (\n p<\/jats:italic>\n = 0.042), and low ion index (ALI) (\n p<\/jats:italic>\n = 0.016) were predictive of poor survival on univariate analysis. Factors found to be prognostic in univariate analysis were evaluated in multivariate analysis. In the established model, only ALI (HR = 0.68, 95% CI: 0.49\u20130.93,\n p<\/jats:italic>\n = 0.016) were found to be an independent prognostic factor for OS. The corresponding mOS according to CALLY, SII, ALI, and ECOG (Eastern Cooperative Oncology Group \u2010 Performance score) performance status were 8 versus 10\u00a0months (\n p<\/jats:italic>\n = 0.020), 10 versus 8\u00a0months (\n p<\/jats:italic>\n = 0.030), 8 versus 9\u00a0months (\n p<\/jats:italic>\n = 0.010), and 9 versus 8\u00a0months (\n p<\/jats:italic>\n = 0.025), respectively, with significant difference.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n CALLY, SII, ALI, and ECOG performance status could be useful prognostic markers for clinicians in patients with ES\u2010SCLC receiving chemotherapy, with ALI emerging as the strongest prognostic factor. These readily accessible and easily computed markers can facilitate cost\u2010effective follow\u2010up and treatment decision\u2010making by providing clinicians with a real\u2010time assessment of the dynamic balance between host immunity and tumor\u2010associated inflammation.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajco.14200","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T22:48:26Z","timestamp":1750286906000},"page":"654-659","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Inflammation\u2010Based Prognostication in Extensive\u2010Stage Small Cell Lung Cancer in the First\u2010Line Setting: The Advanced Lung Inflammation Index and the Others"],"prefix":"10.1111","volume":"21","author":[{"given":"Erdo\u011fan Sel\u00e7uk","family":"\u015eeber","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Faculty of Medicine Tekirdag Namik Kemal University 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