{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:04Z","timestamp":1789168504442,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T00:00:00Z","timestamp":1761091200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate treatment results of a neoadjuvant regimen consisting of Docetaxel + Cisplatin + S\u20101 (DCS) in patients with locoregionally advanced unresectable gastric adenocarcinoma characterized by tumors with bulky regional lymph nodes (T1\u20134a, N\u2010bulky, M0) or T4b tumors (any N, M0)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This study included 78 patients with locoregionally advanced gastric adenocarcinoma treated at a university hospital in Vietnam, comprising 47 retrospective and 31 prospective cases. Patients received 2 \u2010 4 cycles of DCS chemotherapy, with each cycle comprising intravenous docetaxel (35\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) and cisplatin (35\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      ) on days 1 and 15, and oral S\u20101 (40\u00a0mg\/m\n                      <jats:sup>2<\/jats:sup>\n                      \/twice daily) from days 1 to 14, repeated every 4 weeks. Clinical treatment response was assessed after every three cycles and re\u2010staging evaluation by using the RECIST criteria and contrast\u2010enhanced CT scans after 2 \u2010 4 cycles, depending on patient response and tolerability. Patients with a good response and down\u2010staging were referred for gastrectomy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age was 58 years, and 64.1% were male. Following neoadjuvant chemotherapy, the proportion of T4b tumors decreased from 78.2% to 52.6%, while T4a tumors increased from 20.5% to 43.6%. The rate of N\u2010bulky decreased from 23.1% to 11.5%. Anemia and neutropenia were the most common hematological toxicities, predominantly grade 1\u20132. Gastrointestinal toxicity and hair loss were the most frequent clinical adverse events, mostly grade 1\u20132. Among 65 patients (83.3%) achieving an objective response to neoadjuvant chemotherapy, 42 (53.8%) underwent gastrectomy, with R0 resection achieved in 92.9%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Neoadjuvant chemotherapy using the DCS regimen every 4 weeks demonstrated high effectiveness and safety in patients with locoregionally advanced unresectable gastric adenocarcinoma characterized by extensive regional metastases, and increased their eligibility for successful gastrectomy (R0 resection).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>This study is a retrospective and prospective cohort study, not a clinical trial.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70039","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:47:19Z","timestamp":1761126439000},"page":"659-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of Neoadjuvant Chemotherapy With Docetaxel, Cisplatin, and S\u20101 for Locoregionally Advanced Gastric Adenocarcinoma: Findings From a University Hospital in Vietnam"],"prefix":"10.1111","volume":"22","author":[{"given":"Tho Vinh","family":"Tran","sequence":"first","affiliation":[{"name":"Chemotherapy Department University Medical Center Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-8281","authenticated-orcid":false,"given":"Truc Thanh","family":"Thai","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Informatics University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loi Ngoc","family":"La","sequence":"additional","affiliation":[{"name":"Diagnostic Imaging Department University Medical Center Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngon","family":"Van Dinh","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics and Informatics University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vo Duy","family":"Long","sequence":"additional","affiliation":[{"name":"Gastrointestinal Surgery Department University Medical Center Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bac Hoang","family":"Nguyen","sequence":"additional","affiliation":[{"name":"University Medical Center Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.02914"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.9.1318"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000236018"},{"issue":"130","key":"e_1_2_12_6_1","first-page":"512","article-title":"Simple Prognostic Indicators Using Macroscopic Features and Age in Advanced Gastric Cancer","volume":"61","author":"Yamashita K.","year":"2014","journal-title":"Hepato\u2010Gastroenterology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4251\/wjgo.v9.i4.166"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2016.0137"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw350"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-016-0622-4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010010\u20100566\u2010z"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.11.50"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0b013e32832ec02b"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00280\u2010013\u20102073\u20105"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10120\u2010018\u20100884\u20100"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.21614\/sgo\u2010700"},{"key":"e_1_2_12_17_1","volume-title":"Evaluation of the Efficacy of the DCS Regimen in Advanced Gastric Cancer","author":"Nam L. 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