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Treatment modalities like surgery, chemotherapy, and radiotherapy are customarily associated with noxious side effects as well as drug resistance. The food constituent flavonoid quercetin has been identified as anticancer through several mechanisms, including apoptosis induction, suppression of metastasis, cell cycle arrest, and chemosensitization. Its clinical application is, however, restricted by poor systemic absorption. Novel nano\u2010formulations such as liposomes, polymeric nanoparticles, etc., have emerged for improving the stability, bioavailability, and therapeutic action of quercetin. Artificial intelligence has also been reported to be of potential use in predicting patient response to quercetin, recognizing new molecular targets, and customizing treatment regimens. Future research should be conducted with clinical trials to establish the effectiveness of quercetin as an adjuvant treatment and fine\u2010tune targeted delivery systems for it. There is a therapeutic promise for quercetin across multiple types of oral cancer due to its multi\u2010targeting potential. Quercetin, in combination with traditional and immunotherapeutic strategies, represents a promising new strategy with the potential to overcome treatment barriers and reduce toxicity in oral cancer management.<\/jats:p>","DOI":"10.1111\/ajco.70046","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T10:09:49Z","timestamp":1763114989000},"page":"692-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quercetin as a Therapeutic Agent for Oral Cancer: Current Evidence and Future Directions"],"prefix":"10.1111","volume":"22","author":[{"given":"Hua","family":"Sun","sequence":"first","affiliation":[{"name":"Oral Cavity Teaching and Research Section, Medical School Hebi Polytechnic College  Hebi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurology The Second People's Hospital of Xinxiang  Xinxiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujiang","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Stomatology General Hospital of Hebi Coal Industry (Group) Co  Hebi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,14]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04690-z"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.5530\/jyp.2018.10.32"},{"key":"e_1_2_16_4_1","volume-title":"Understanding the Impact of Intensity Modulated Radiation Therapy on Dental and Oral Tissues in Oropharyngeal Cancer Patients","author":"Patel V.","year":"2020"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01607-9"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-021-00537-2"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2025.e42682"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2025.125308"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1535682"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-91920-7_34"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijom.2024.07.001"},{"key":"e_1_2_16_12_1","unstructured":"C.Jenno.Comparing Oral Squamous Cell Carcinoma In Young Vs Old Patients: Clinical Features Treatment and Prognosis: A Systematic Review [Final Project Universidad Europea Valencia]. 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