{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:15:08Z","timestamp":1789168508306,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The cost of treating cancer, especially metastatic disease, can place a financial burden on patients, caregivers, and the healthcare system. A previous systematic review assessing the cost of treating metastatic colorectal cancer in the era of personalized medicine showed that this was approximately 300,000 USD. Surprisingly, there is little data on the cost of treating patients with colorectal liver metastases (CRLM). The aim of this study was to conduct a pilot cost\u2010of\u2010illness study on patients who undergo liver resection for CRLM in Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a retrospective cohort study examining the direct medical costs to the healthcare system and out\u2010of\u2010pocket costs to patients who underwent resection for CRLM in 1 year (2018). These costs were calculated in 2022 Australian dollars from the time of the diagnosis of the liver metastases to the time of the last follow\u2010up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25 patients underwent resection in 2018, but only 16 received all their treatment at the Northern Campus. The median total cost of treating each patient was $328,773.59 (range: $63,244.40\u2013$525,873.10). The highest cost was for medical oncology treatment, with a median of $90,228.87 per patient (range: $2087.06\u2013$241,514.80), followed by liver surgery and consultations, $57,131.76 (range: $12,455.10\u2013$319,178.90), and colorectal surgery and consultations, $55,990.29 (range: $7234.19\u2013$200,755.60). Patients considered to be cured of their disease had a lower median cost than patients who had either died from their disease or were undergoing treatment for recurrent disease ($152,476.50\u00a0vs. $351,487.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.030).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that the cost of treating patients with CRLM in Australia is moderate but is considerably lower than many other cancer types, especially for those who are cured, reflecting good value care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70056","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:57:23Z","timestamp":1763445443000},"page":"749-756","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost of Treating Patients Who Undergo Resection of Colorectal Liver Metastases: An Australian Pilot Study"],"prefix":"10.1111","volume":"22","author":[{"given":"Nazim","family":"Bhimani","sequence":"first","affiliation":[{"name":"Upper Gastrointestinal Surgical Unit Royal North Shore Hospital  St Leonards NSW Australia"},{"name":"Faculty of Medicine and Health University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Seton","sequence":"additional","affiliation":[{"name":"Colorectal Surgical Department Royal North Shore Hospital  St Leonards NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Chan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of Sydney  Sydney NSW Australia"},{"name":"Medical Oncology Department Royal North Shore Hospital  St Leonards NSW Australia"},{"name":"GenesisCare, North Shore Health Hub  St Leonards NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mbathio","family":"Dieng","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick J.","family":"Kelly","sequence":"additional","affiliation":[{"name":"Sydney School of Public Health University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Hugh","sequence":"additional","affiliation":[{"name":"Upper Gastrointestinal Surgical Unit Royal North Shore Hospital  St Leonards NSW Australia"},{"name":"Northern Clinical School University of Sydney  Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Australian Institute of Health and Welfare Health System Expenditure on Cancer and Other Neoplasms in Australia 2015\u201316(Australian Institute of Health and Welfare 2021)."},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01438-6"},{"key":"e_1_2_13_4_1","first-page":"E296","article-title":"\"Opportunistic Care\": A Focus Group Study of Nurses' Perspective on Caring for Long\u2010Term Cancer Survivors and Their Families","volume":"45","author":"Elizondo Rodr\u00edguez N.","year":"2024","journal-title":"Cancer Nursing"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0116-z"},{"issue":"1","key":"e_1_2_13_6_1","first-page":"104","article-title":"An Overview of Colorectal Cancer in the Australian Healthcare System Over the Past 20 Years","volume":"1","author":"Bhimani N.","year":"2021","journal-title":"Frontiers in Gastroenterology & Hepatology"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2022-327736"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-022-01497-z"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2022.06.022"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.003"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41698-023-00353-4"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01690"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00600-4"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.21147\/j.issn.1000-9604.2019.05.12"},{"issue":"2","key":"e_1_2_13_15_1","first-page":"S34","article-title":"Analyzing the Variation in Treatment Costs for Colorectal Cancer (CRC): A Retrospective Study to Assess an Underlying Threat Among the Vietnamese","volume":"69","author":"Le N. 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