{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:17:15Z","timestamp":1783480635313,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The Pharmaceutical Benefits Scheme (PBS) provides affordable access to cancer treatments in Australia. Not all cancer treatments are available on the PBS. Access to non\u2010PBS\u2010listed cancer treatments can occur through Compassionate Access Programs (CAPs). This retrospective review describes cancer treatments used via CAPs in a Metropolitan Cancer Centre in Australia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with solid organ malignancies who had received drugs via compassionate access between 2017 and 2024 were identified via pharmacy and hospital medical records. Patients with hematological malignancies or who accessed drugs through out\u2010of\u2010pocket funding were excluded. CAPs were grouped into cost\u2010share\/co\u2010pay and cost\u2010free programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 228 cases, 148 (64.9%) received the drug cost\u2010free, and 80 (35.1%) were on a cost\u2010share\/co\u2010pay program. A total of 110 (48.2%) patients received the CAP drug as their first therapy. The median number of previous therapies before receiving CAP drug was 1 (range: 0\u20134). The median duration between diagnosis and use of CAP drug was 5.1 months (range: 0.2\u201396.0). The median and mean duration of CAP drug use were 5.2 and 10.3 months, respectively (range: 0.03\u201396.0). A total of 53 programs provided 40 drugs from 18 companies. Six drugs had both cost\u2010share\/co\u2010pay and cost\u2010free programs. The drug with the most patients was pertuzumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a043), followed by nivolumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a027) and durvalumab (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a021). Fourteen patients accessing non\u2010oral drugs via cost\u2010share\/co\u2010pay programs ultimately did not receive any free drugs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There is an increasing prevalence of novel drug use via CAPs across all types of cancers with promising impacts on patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70071","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T03:39:32Z","timestamp":1769139572000},"page":"501-507","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Compassionate Access Drug Use for Solid Organ Malignancies in a Metropolitan Cancer Centre in Australia Between 2017 and 2024"],"prefix":"10.1111","volume":"22","author":[{"given":"Yun San","family":"Chong","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7767-6285","authenticated-orcid":false,"given":"Nicholas","family":"Yeo","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Medical Oncology Prince of Wales Hospital  Randwick New South Wales Australia"},{"name":"Department of Medical Oncology Wollongong Hospital  Wollongong New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Redmayne","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melvin","family":"Chin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health University of New South Wales  Sydney New South Wales Australia"},{"name":"Department of Medical Oncology Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa011954"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00174"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.04.478"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00581"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.01989"},{"key":"e_1_2_8_7_1","unstructured":"Federal Register of Legislation Department of Health and Aged Care Therapeutic Goods Act 1989(Federal Register of Legislation 2024) https:\/\/www.legislation.gov.au\/C2004A03952\/latest\/text."},{"key":"e_1_2_8_8_1","unstructured":"Pharmaceutical Benefits Scheme Department of Health and Aged Care Procedure Guidance for Listing Medicines on the Pharmaceutical Benefits Scheme(Pharmaceutical Benefits Scheme 2022) https:\/\/www.pbs.gov.au\/info\/industry\/listing\/listing\u2010steps."},{"key":"e_1_2_8_9_1","unstructured":"Parliament of Australia Availability of New Innovative and Specialist Cancer Drugs in Australia(Parliament of Australia 2015) https:\/\/www.aph.gov.au\/Parliamentary_Business\/Committees\/Senate\/Community_Affairs\/Cancer_Drugs."},{"key":"e_1_2_8_10_1","unstructured":"CoATA Groups Managing Medicines Access Programs(CoATA Groups 2018)."},{"key":"e_1_2_8_11_1","unstructured":"TPGo Australia Medicines Access Programs (MAP)(Pharmacy Guild of Australia 2018) https:\/\/www.guild.org.au\/__data\/assets\/pdf_file\/0024\/56346\/Medicines\u2010Access\u2010Programs\u2010MAP.pdf."},{"key":"e_1_2_8_12_1","unstructured":"Economics DA Access to Cancer Medicines in Australia(MOGA 2013)."},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2012.02750.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cnr2.1404"},{"key":"e_1_2_8_15_1","first-page":"188","article-title":"Compassionate Supply of Oncology Drugs Within the South Eastern Sydney Local Health District (SESLHD) in 2011\u20132015","volume":"13","author":"Chin T. 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C.","year":"2017","journal-title":"Asia\u2010Pacific Journal of Clinical Oncology"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healthpol.2017.12.004"},{"key":"e_1_2_8_17_1","unstructured":"Medicines Australia MAP Offers New Online Pathway for Accessing Cancer Treatments Press Release (Medicines Australia 2023)."},{"key":"e_1_2_8_18_1","unstructured":"Australian Bureau of Statistics Socio\u2010Economic Indexes for Areas (SEIFA) Australia(Australian Bureau of Statistics 2023)."},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17742"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2641"},{"key":"e_1_2_8_21_1","volume-title":"Access to unapproved therapeutic goods for individual patients (Special Access Scheme)","author":"Australian Government Department of Health and Aged Care","year":"2025"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/2168479017694850"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.21568"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-023-02978-x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-016-1025-6"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.70071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:54:52Z","timestamp":1783479292000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.70071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ajco.70071"],"URL":"https:\/\/doi.org\/10.1111\/ajco.70071","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"2025-02-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}