{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T04:13:45Z","timestamp":1775535225984,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To describe the treatment pattern and outcomes for patients with extracranial, extragonadal germ cell tumors (EGCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of male patients with EGCT prospectively registered in the Australian GCT clinical registry (iTestis) since its inception in 2018. Demographics, clinicopathologic features, treatment characteristics, and outcomes were recorded. Data were analyzed using descriptive statistics and the Kaplan\u2013Meier method estimates of overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 1256 patients in the iTestis registry, 33 (3%) had EGCT including 18 (55%) with mediastinal, 14 (42%) with retroperitoneal, and 1 (3%) with a lung primary. The median age was 31 years (range: 24\u201338), ECOG performance status was 0\u20131 in 26 (79%), and 21 (64%) were non\u2010seminoma.<\/jats:p>\n                    <jats:p>\n                      Chemotherapy was administered upfront in 27 (82%) patients, upfront surgery in four patients (12%), and treatment was unknown in two (6%) patients. The most common chemotherapy regimen was bleomycin\/etoposide\/cisplatin (BEP) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a020, 74%), followed by etoposide\/ifosfamide\/cisplatin (VIP) (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a05, 19%) and EP (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02, 7%). Post\u2010chemotherapy surgery was carried out in 16 (59%) patients, and 4 (15%) patients received second\u2010line chemotherapy.\n                    <\/jats:p>\n                    <jats:p>\n                      At a median follow\u2010up of 22.7 months (range: 0\u2013126), no deaths were observed in individuals with retroperitoneal primary (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a014), seminoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a012), or International Germ Cell Cancer Collaborative Group (IGCCCG) good (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a015) and intermediate risk (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a03) disease. Three deaths occurred in patients with mediastinal non\u2010seminoma. The estimated 24\u2010month OS for mediastinal non\u2010seminoma and IGCCCG poor risk disease was 71% (95% confidence interval [CI]: 27%\u201394%) and 79% (95% CI: 25%\u201395%), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Incidence of EGCT in Australia is consistent with published literature. Treatment patterns reflect international practices. Primary mediastinal non\u2010seminoma has the poorest outcomes. Primary retroperitoneal and primary mediastinal seminomas have excellent outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70083","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T08:35:36Z","timestamp":1769675736000},"page":"404-410","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extracranial, Extragonadal Germ Cell Tumors: A Multicenter Australian Case Series"],"prefix":"10.1111","volume":"22","author":[{"given":"Kar Ven Cavan","family":"Chow","sequence":"first","affiliation":[{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Medical Oncology Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciara","family":"Conduit","sequence":"additional","affiliation":[{"name":"Personalised Oncology Division Walter and Eliza Hall Institute of Medical Research  Parkville Victoria Australia"},{"name":"Department of Medical Oncology Royal Hobart Hospital  Hobart Tasmania Australia"},{"name":"Sir Peter Maccallum Department of Oncology University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophie","family":"O'Haire","sequence":"additional","affiliation":[{"name":"Personalised Oncology Division Walter and Eliza Hall Institute of Medical Research  Parkville Victoria Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Kuchel","sequence":"additional","affiliation":[{"name":"School of Medicine The University of Queensland  Brisbane Queensland Australia"},{"name":"Department of Medical Oncology Royal Brisbane and Women's Hospital  Brisbane Queensland 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