{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:17:15Z","timestamp":1783480635298,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004331","name":"Johnson and Johnson","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022896","name":"Australian and New Zealand Urogenital and Prostate Cancer Trials Group","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022896","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>The aim of the fourth Asia\u2010Pacific Advanced Prostate Cancer Symposium (APAC APCS 2025) was to discuss the application in the Asia\u2010Pacific (APAC) region of outcomes from the fifth Advanced Prostate Cancer Consensus Conference (APCCC 2024).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The one\u2010day symposium in September 2025 brought together 28 experts from 15 APAC countries or regions. The symposium covered five topics: (1) high\u2010risk localized\/locally advanced prostate cancer; (2) prostate\u2010specific antigen persistence and recurrence; (3) radioligand therapy; (4) genetics and genomics; (5) bone protection and other aspects of supportive care. Presymposium polling and expert presentations prefaced in\u2010depth discussions to gather insights on current practice and challenges in the region.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      APAC APCS 2025 highlighted the increasing complexities in diagnosis and management of advanced prostate cancer and the impact on practice of variations in access and cost. Panelists described variations in access and reimbursement for PSMA\u2010PET\/CT, abiraterone, androgen receptor pathway inhibitors,\n                      <jats:sup>177<\/jats:sup>\n                      Lu\u2010PSMA, and bone\u2010protecting agents. While most panelists reported access to nuclear medicine expertise, access to genetic counsellors continues to be limited in many parts of the region. Discussions highlighted creative approaches used to minimize costs while maximizing options for patients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>APAC Advanced Prostate Cancer Symposia are important forums for discussing APAC\u2010specific considerations in areas where clinical evidence is evolving. In an era of increasingly sophisticated technologies, discussions highlight the importance of not losing sight of patient and clinical factors in decision\u2010making. Multidisciplinary and personalized management is critical, along with the need for locally relevant data to inform APAC\u2010specific guidelines.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70092","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:53:35Z","timestamp":1772988815000},"page":"546-556","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of Advanced Prostate Cancer in the Asia\u2010Pacific Region: Summary of the Asia\u2010Pacific Advanced Prostate Cancer Symposium 2025"],"prefix":"10.1111","volume":"22","author":[{"given":"Edmund","family":"Chiong","sequence":"first","affiliation":[{"name":"Department of Urology National University Hospital  Singapore Singapore"},{"name":"Department of Surgery Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renu","family":"Eapen","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Department of Genitourinary Oncology Peter MacCallum Cancer Centre  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Buchan","sequence":"additional","affiliation":[{"name":"Department of Urology Christchurch Public Hospital  Christchurch New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Urology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukman","family":"Hakim","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine Universitas Airlangga  Surabaya Indonesia"},{"name":"Department of Medicine Faculty of Medicine and Health Institut Teknologi Sepuluh Nopember  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agus Rizal","family":"Hamid","sequence":"additional","affiliation":[{"name":"Department of Urology Faculty of Medicine Universitas Indonesia \u2013 Cipto Mangunkusumo Hospital Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae\u2010Young","family":"Joung","sequence":"additional","affiliation":[{"name":"Department of Urology Center for Urological Cancer National Cancer Center  Goyang South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindran","family":"Kanesvaran","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology National Cancer Centre Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makarand","family":"Khochikar","sequence":"additional","affiliation":[{"name":"Department of Urology\/Uro\u2010oncology Ushakal Abhinav Institute of Medical Sciences  Sangli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Letran","sequence":"additional","affiliation":[{"name":"Department of Urology Chinese General Hospital and Medical Center  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bannakij","family":"Lojanapiwat","sequence":"additional","affiliation":[{"name":"Department of Surgery Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indranil","family":"Mallick","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Tata Medical Center  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Fai","family":"Ng","sequence":"additional","affiliation":[{"name":"SH Ho Urology Centre The Chinese University of Hong Kong  Ma Liu Shu Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei Ing","family":"Ngam","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng Aik","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Surgery Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Urology Chang Gung Memorial Hospital Linkou  Taoyuan Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren M. C.","family":"Poon","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology The Chinese University of Hong Kong  Ma Liu Shu Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Roberts","sequence":"additional","affiliation":[{"name":"STARS Education and Research Alliance Metro North Health and The University of Queensland  Herston Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marniza","family":"Saad","sequence":"additional","affiliation":[{"name":"Department of Clinical Oncology Faculty of Medicine Universiti Malaya  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Urology Chiba University Graduate School of Medicine  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Tey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National University Cancer Institute Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue Ping","family":"Thang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine and Molecular Imaging Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Poh Choo","family":"Toh","sequence":"additional","affiliation":[{"name":"Department of Urology National University Hospital and Department of Surgery, National University of Singapore  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"T\u00fcrkeri","sequence":"additional","affiliation":[{"name":"Department of Urology Altunizade Hospital, Acibadem M.A. Aydinlar University  Istanbul T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguy\u1ec5n Tu\u1ea5n","family":"Vinh","sequence":"additional","affiliation":[{"name":"Department of Urology Binh Dan Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Haematology Oncology National University Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Urology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"ANZUP Cancer Trials Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9066-8244","authenticated-orcid":false,"given":"Ian D.","family":"Davis","sequence":"additional","affiliation":[{"name":"Monash University  Melbourne Victoria Australia"},{"name":"Eastern Health  Melbourne Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,1]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.09.017"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.14489"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13722"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.14064"},{"key":"e_1_2_7_6_1","unstructured":"National Comprehensive Cancer Network.NCCN Guidelines Prostate Cancer Version 2.2026. [Accessed 25 October 2025] https:\/\/www.nccn.org\/guidelines\/guidelines\u2010detail?id=1459."},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02437-5"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.22.00970"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00705-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30528-X"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2016.06.2455"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2024.03.023"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03282"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.04.010"},{"key":"e_1_2_7_15_1","first-page":"20","article-title":"Complications of Pelvic Lymphadenectomy: Do the Risks Outweigh the Benefits?","volume":"12","author":"Loeb S.","year":"2010","journal-title":"Reviews in Urology"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.02.001"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.3771"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31553-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30454-X"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30456-3"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912093412401"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2024.0019"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000002757"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2021.01.001"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2020.07.2103"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.06.021"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2019.01.049"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107322"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01653-2"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.07.003"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2025.1530580"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00237-3"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-025-07438-1"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(25)00009-9"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06255-8"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.03488"},{"key":"e_1_2_7_37_1","unstructured":"Study Evaluating mCRPC Treatment Using PSMA [Lu\u2010177]\u2010PNT2002 Therapy After Second\u2010Line Hormonal Treatment (SPLASH). ClinicalTrials.gov: NCT04647526 [Accessed 25 October 2025]. Available at:https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT04647526."},{"key":"e_1_2_7_38_1","unstructured":"177Lu\u2010PSMA\u2010I&T for Metastatic Castration\u2010Resistant Prostate Cancer. ClinicalTrials.gov: NCT05204927 [Accessed 25 October 2025]. Available at:https:\/\/clinicaltrials.gov\/study\/NCT05204927."},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1483953"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.23.02105"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.001"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1411"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2025.05.534"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-24-2483"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.13511"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7010"},{"issue":"4","key":"e_1_2_7_47_1","article-title":"Niraparib Plus Abiraterone Acetate Plus Prednisone (NIRA+AAP) as First\u2010Line Treatment in Patients With BRCA+ Metastatic Castration\u2010Resistant Prostate Cancer (mCRPC): Second Interim Analysis in the Asian Subgroup of the MAGNITUDE Study","volume":"34","author":"Saad M.","year":"2023","journal-title":"Annals of Oncology"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000007223"},{"key":"e_1_2_7_49_1","volume-title":"EUA\u2014EANM\u2014ESTRO\u2014ESUR\u2014ISUP\u2014SIOG Guidelines on Prostate Cancer","author":"Cornford P.","year":"2025"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.06.011"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30860-X"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.11.027"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2024.12.016"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.07.019"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31090366"},{"key":"e_1_2_7_56_1","volume-title":"A Psychosocial Care Model for Men With Prostate Cancer: An Essential Element of the Prostate Cancer Survivorship Essentials Framework. Guide for Health Care Professionals","author":"Dunn J.","year":"2022"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70035"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.76.4381"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70092","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.70092","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T02:55:29Z","timestamp":1783479329000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.70092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,1]]},"references-count":57,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/ajco.70092"],"URL":"https:\/\/doi.org\/10.1111\/ajco.70092","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,1]]},"assertion":[{"value":"2026-01-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}