{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:17:09Z","timestamp":1783480629349,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study aimed to review the outcomes for patients with microinvasive and small HER2+ breast cancers, compare the clinicopathological features, and explore the patterns of care.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this single\u2010center retrospective study, patients with HER2+, pT1mic\u2010bN0M0 disease who underwent surgery in Northern Sydney Local Health District between 2006 and 2022 were selected. The primary outcome was invasive disease\u2010free survival (iDFS), and secondary outcome was overall survival (OS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the 32 eligible patients, those with pT1b disease had higher histological grades and Ki\u201067 indices, with a higher rate of trastuzumab administration. One recurrence and one death were observed in the pT1a group. The 5\u2010year iDFS and OS were 93% for the pT1mic\/a group and 100% for the pT1b group (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.29). Sixty\u2010six percent of patients received adjuvant trastuzumab. Trastuzumab prescription was associated with larger tumor sizes (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.008) and higher histologic grades (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.023).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Patients with microinvasive or small HER2+ node\u2010negative breast cancer experience favorable outcomes. The pT1b group had higher histological grades and proliferative indices. Patients with pT1b disease or higher tumor grades were more likely to receive trastuzumab. While trastuzumab is recommended for pT1b disease with strong evidence, its use in pT1a disease should be balanced against its unclear benefits and known toxicities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70100","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T10:30:31Z","timestamp":1773829831000},"page":"564-572","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Outcomes for Patients With Micro\u2010Invasive or Small HER2+ Breast Cancer in Northern Sydney Local Health District"],"prefix":"10.1111","volume":"22","author":[{"given":"Yuanyuan","family":"Xue","sequence":"first","affiliation":[{"name":"Northern Clinical School The University of Sydney  Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrina","family":"Moore","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"Saurine","sequence":"additional","affiliation":[{"name":"Department of Anatomical Pathology New South Wales Health Pathology Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Northern Sydney Cancer Centre Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Pugliano","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Northern Sydney Cancer Centre Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8877-3440","authenticated-orcid":false,"given":"Connie","family":"Diakos","sequence":"additional","affiliation":[{"name":"Northern Clinical School The University of Sydney  Camperdown New South Wales Australia"},{"name":"Department of Medical Oncology Northern Sydney Cancer Centre Royal North Shore Hospital  St Leonards New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602075"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.53.1608"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/tbj.13288"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010023\u201006955\u20107"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083646"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4263"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549\u2010012\u20102236\u20109"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010012\u20100201\u20104"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.607502"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11639"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052306"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","unstructured":"E. 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