{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T03:17:19Z","timestamp":1783480639929,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,3,22]],"date-time":"2026-03-22T00:00:00Z","timestamp":1774137600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lenalidomide, bortezomib, and dexamethasone (RVD) remains a standard of care regimen for newly diagnosed multiple myeloma in centers without access to upfront anti\u2010CD38 therapy within the Asia\u2010Pacific. However, regimens proven efficacious in clinical trials utilize twice\u2010weekly bortezomib, which is now thought to confer unacceptable toxicity, particularly in transplant\u2010ineligible patients. There is a paucity of prospective data on RVD treatment schedules utilizing weekly bortezomib, which has implications for health care systems implementing standardized treatment based on clinical trial evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Eighty\u2010three patients with newly diagnosed transplant\u2010ineligible multiple myeloma from six hospitals in Australia, received one of two RVD regimens utilizing weekly subcutaneous bortezomib (Modified SWOG and Modified RVD Lite) pragmatically adapted from their corresponding clinical trials. Baseline characteristics, response rates, toxicities, and survival were assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At a median follow\u2010up of 27.4 months, Modified SWOG achieved an ORR 91.4%, \u2265 VGPR 71.4%, and 24\u2010month progression\u2010free survival (PFS) of 63.1% (95% CI: 47.6\u201383.5). Modified RVD Lite achieved an ORR 93.9%, \u2265 VGPR 64.7%, and 24\u2010month PFS of 53.6% (95% CI: 39.1\u201373.4). Despite dose attenuation, significant toxicity was still seen overall with hospitalizations in 48.2% and premature cessation due to toxicity in 31.3%. Peripheral sensory neuropathy was lower than in published clinical trials, reported in 32 (38.6%) patients, with Grade 3 events in only 2 patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study demonstrates that real\u2010world outcomes of weekly RVD regimens have comparable efficacy to published twice\u2010weekly regimens; however, toxicity remains a significant challenge in this patient population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70101","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T06:29:01Z","timestamp":1774247341000},"page":"573-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy and Tolerability of Weekly Bortezomib, Lenalidomide, and Dexamethasone Protocols in Transplant\u2010Ineligible Newly Diagnosed Myeloma: An Australian Real\u2010World, Multicenter Study"],"prefix":"10.1111","volume":"22","author":[{"given":"Samantha","family":"Kurniawan","sequence":"first","affiliation":[{"name":"Liverpool Hospital  Liverpool Australia"},{"name":"School of Clinical Medicine UNSW Medicine and Health UNSW Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Hwang","sequence":"additional","affiliation":[{"name":"St Vincent's Hospital  Darlinghurst Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole Wong","family":"Doo","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital  Concord Australia"},{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"King","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health The University of Sydney  Sydney Australia"},{"name":"Royal Prince Alfred Hospital  Camperdown Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Bryant","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital  Camperdown Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Zhang","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital  Concord Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Whelan","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital  Camperdown Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parisa","family":"Fani\u2010Molky","sequence":"additional","affiliation":[{"name":"Concord Repatriation General Hospital  Concord Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Kidson\u2010Gerber","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine UNSW Medicine and Health UNSW Sydney  Sydney Australia"},{"name":"Prince of Wales Hospital  Randwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annmarie","family":"Bosco","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine UNSW Medicine and Health UNSW Sydney  Sydney Australia"},{"name":"Prince of Wales Hospital  Randwick Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nada","family":"Hamad","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine UNSW Medicine and Health UNSW Sydney  Sydney Australia"},{"name":"St Vincent's Hospital  Darlinghurst Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurdeep","family":"Parmar","sequence":"additional","affiliation":[{"name":"Wollongong Hospital  Wollongong Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Kwok","sequence":"additional","affiliation":[{"name":"Westmead Hospital  Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam","family":"Lai","sequence":"additional","affiliation":[{"name":"Westmead Hospital  Westmead Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Ling","sequence":"additional","affiliation":[{"name":"Liverpool Hospital  Liverpool Australia"},{"name":"School of Clinical Medicine UNSW Medicine and Health UNSW Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. 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