{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T08:39:08Z","timestamp":1792658348289,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Giant cell tumor of bone (GCTB) is a rare, locally aggressive osteolytic neoplasm associated with a substantial risk of local recurrence and challenging surgical management. Denosumab, a monoclonal antibody, has emerged as a promising therapeutic option. This study evaluates the efficacy of denosumab as a neoadjuvant therapy in patients with Grade III GCTB, with particular emphasis on tumor recurrence, ossification, and surgical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective, non\u2010randomized comparative interventional study, 34 adults with histologically confirmed Campanacci Grade III GCTB were enrolled and prospectively followed. Sixteen patients received neoadjuvant denosumab and 18 contemporaneous patients underwent surgery without neoadjuvant denosumab. Treatment allocation was based on routine clinical decision\u2010making and patient\u2010specific factors rather than randomization.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      During the 18\u2010month follow\u2010up period, local recurrence occurred in 2 of 16 patients (12.5%) in the denosumab intervention group and in 8 of 18 patients (44.4%) in the comparison group (\n                      <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                      0.063). Radiological ossification was observed in all patients in the denosumab group and in none of the patients in the comparison group. Curettage and cementation were performed in 14 patients (87.5%) in the intervention group and 12 patients (66.7%) in the comparison group; this difference was not statistically significant (\n                      <jats:italic>p\u00a0=\u00a0<\/jats:italic>\n                      0.233). Qualitative histopathological assessment of available specimens from denosumab\u2010treated patients demonstrated marked depletion or disappearance of osteoclast\u2010like giant cells, accompanied by treatment\u2010related changes including new bone formation, fibrosis, and hemorrhage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this study, neoadjuvant denosumab was associated with complete radiological ossification, qualitative histopathological changes characterized by marked depletion of osteoclast\u2010like giant cells, and numerically lower observed local recurrence and greater use of curettage and cementation, although the latter two between\u2010group differences were not statistically significant.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70153","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T03:10:48Z","timestamp":1786677048000},"page":"853-860","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Efficacy of Neoadjuvant Denosumab on Tumor Recurrence, Ossification, and Surgical Outcomes in Patients With Grade III Giant Cell Tumor of Bone: A Prospective, Non\u2010Randomized Comparative Interventional Study"],"prefix":"10.1111","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4388-0214","authenticated-orcid":false,"given":"Mehdi","family":"Karimi","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9220-3891","authenticated-orcid":false,"given":"Samira","family":"Pirzad","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimia","family":"Habibi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3585-9379","authenticated-orcid":false,"given":"Masoud","family":"Mirkazemi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Faculty of Medicine Islamic Azad University, Tehran Medical Sciences Branch  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"issue":"1","key":"e_1_2_13_2_1","first-page":"2","article-title":"Giant Cell Tumor of Bone\u2014An Overview","volume":"4","author":"Sobti A.","year":"2016","journal-title":"Archives of Bone and Joint Surgery"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1302\/0301\u2010620X.105B5.BJJ\u20102022\u20101231.R1"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13102870"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000852"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorep.2024.100384"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36332"},{"issue":"10","key":"e_1_2_13_8_1","article-title":"Giant Cell Tumour of Bone: A Comprehensive Review of Pathogenesis, Diagnosis, and Treatment","volume":"15","author":"Jha Y.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277\u2010015\u20103094\u2010y"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad196"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885\u2010020\u201007739\u20108"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2024.14520"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115680096265253231022185008"},{"issue":"4","key":"e_1_2_13_14_1","first-page":"260","article-title":"Denosumab in Patients With Giant Cell Tumor and Its Recurrence: A Systematic Review","volume":"6","author":"Jamshidi K.","year":"2018","journal-title":"Archives of Bone and Joint Surgery"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00402\u2010019\u201003167\u2010x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13244\u2010020\u201000845\u2010y"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aott.2016.03.004"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0000000000000529"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2017.02.008"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017\u201002025"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11864\u2010020\u201000766\u20104"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1530\/EOR\u201023\u20100138"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256\u2010023\u201004403\u20107"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.17.00057"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.esmoop.2024.102548"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184664"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol31040160"},{"issue":"7","key":"e_1_2_13_28_1","article-title":"Outcomes in Bone Giant Cell Tumors Treated with Surgical Resection with and without Denosumab Injection: A Single\u2010Institution Retrospective Study","volume":"14","author":"AlYami A. H.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_13_29_1","volume-title":"StatPearls","author":"Hosseinzadeh S.","year":"2024"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1051\/sicotj\/2017041"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672\u2010024\u201000918\u20100"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.O.00156"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70153","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.70153","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70153","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:53:31Z","timestamp":1792655611000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.70153"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["10.1111\/ajco.70153"],"URL":"https:\/\/doi.org\/10.1111\/ajco.70153","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"2025-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}