{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T06:07:24Z","timestamp":1789020444866,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Extended reality (XR) technologies, including augmented reality (AR), mixed reality (MR), and virtual reality (VR), are an appealing technology in clinical oncology. This narrative review evaluates the current evidence of XR applications throughout the cancer care continuum in terms of the clinical implementation, patient outcome, and the relevance of the practice to practicing clinical oncologists.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A literature search on PubMed, Scopus, Web of Science, and Cochrane Library (January 2015\u2013December 2025) was conducted at the right time to select the articles related to AR, VR, MR, XR, and cancer\/oncology. Randomized controlled trials (RCTs), systematic reviews, meta\u2010analyses, and clinical implementation studies were given priority.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      VR contains the strongest evidence base in which 15 RCTs meta\u2010analysis (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a0864) found large reductions in the level of anxiety related to chemotherapy (standardized mean difference [SMD]\u00a0=\u00a0\u22121.40) among adult patients with cancer and fatigue (SMD\u00a0=\u00a0\u22123.85). Cancer\u2010related pain (SMD\u00a0=\u00a0\u22120.86, 95% CI: \u22121.89 to \u22120.85,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) affected significantly VR interventions as well when implemented in 28 RCTs. In hepatic, glioma, and gastrointestinal tumor resection, AR\u2010guided surgical navigation has been clinically workable, and prospective research has indicated that it is capable of better tumor localization. Depression (SMD\u00a0=\u00a0\u22121.86,\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) was also reduced. The 3D holographic visualization with the help of MR enables the treatment planning of the multidisciplinary type.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The XR technologies possess immense potential in the field of personalized oncology. The sphere of VR\u2010based supportive care intervention is clinically prepared, and still the uses of AR and MR in surgical oncology require confirmation of multicenter trials. Standardization of the protocols, cost\u2010effectiveness studies and its integration into the clinical processes are yet to remain on the list of the top priorities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/ajco.70172","type":"journal-article","created":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:52:00Z","timestamp":1789019520000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Augmented Reality, Mixed Reality, Virtual Reality, and Extended Reality Applications in Personalized Oncology and Patient\u2010Centered Cancer Care: A Narrative Review"],"prefix":"10.1111","author":[{"given":"Malarkodi","family":"Velraj","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy School of Pharmaceutical Sciences Vels Institute of Science, Technology &amp; Advanced Studies  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepalakshmi","family":"Mani","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice JSS College of Pharmacy JSS Academy of Higher Education &amp; Research  Ooty Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun Kanniyappan","family":"Parthasarathy","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice JSS College of Pharmacy JSS Academy of Higher Education &amp; Research  Ooty Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijayakumar","family":"Murugesan","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics School of Pharmacy JSS Academy of Higher Education and Research  Vacoas\u2010Phoenix Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kommu","family":"Pradeep","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences Villa College  Mal\u00e9 Maldives"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surabhi","family":"Panneerselvam","sequence":"additional","affiliation":[{"name":"SCS Pre\u2010University College  Mangaluru Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panneerselvam","family":"Theivendren","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry &amp; Analysis School of Pharmaceutical Sciences Vels Institute of Science, Technology &amp; Advanced Studies  Chennai Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.fhj.2025.100483","article-title":"Extended Reality in Supporting Cancer Patients and Survivors; A Systematic Review on the Benefits and Challenges Across the Cancer Care Continuum","volume":"13","author":"Elkefi S.","year":"2025","journal-title":"Future Healthcare Journal"},{"issue":"11","key":"e_1_2_11_3_1","article-title":"Oncological Horizons: The Synergy of Medical and Surgical Innovations in Cancer Treatment","volume":"15","author":"Shams M.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","DOI":"10.1177\/21501319241293311","article-title":"Immersive Technologies in Healthcare: An in\u2010Depth Exploration of VR and AR in Enhancing Patient Care, Medical Education, and Training Paradigms","volume":"15","author":"Iqbal A. 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