{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:57:39Z","timestamp":1790567859922,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:00:00Z","timestamp":1790467200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Asia-Pac J Clncl Oncology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Radiotherapy (RT) is the primary treatment for non\u2010metastatic nasopharyngeal cancer (NPC). While intensity\u2010modulated RT (IMRT) is preferred in wealthy regions, three\u2010dimensional conformal RT (3D\u2010CRT) remains common in resource\u2010limited settings. This study evaluated IMRT versus 3D\u2010CRT for NPC, focusing on survival, tumor control, and toxicities.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n This retrospective cohort study, performed at the Cancer Institute of Iran from 2007 to 2024, assessed individuals with non\u2010metastatic nasopharyngeal carcinoma (NPC). Demographic data, treatment details, recurrence rates, metastasis, and survival information were obtained from medical records and follow\u2010up telephone interviews. Complications associated with treatment were classified according to Common Terminology Criteria for Adverse Events v5.0 (2017). Statistical studies were conducted utilizing R software, accompanied with a\n p<\/jats:italic>\n \u2010value.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 176 patients were enrolled, with 124 receiving 3D\u2010CRT and 52 receiving IMRT. IMRT was associated with a significantly reduced incidence of dysphagia and with reduced severity of trismus, dysphagia, xerostomia, and hearing impairment. No significant differences were observed in the incidence or severity of neck stiffness or oral mucositis between the two groups. Concerning treatment results, no statistically significant differences were seen in disease\u2010free survival or metastasis\u2010free survival. The overall survival exhibited a non\u2010significant trend favoring IMRT.<\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n IMRT markedly diminishes several treatment\u2010associated complications in comparison to 3D\u2010CRT; however, it does not provide a definitive survival advantage yet. Extended follow\u2010up and prospective investigations are necessary to elucidate the disparities in long\u2010term efficacy between the two approaches.<\/jats:p>\n <\/jats:sec>\n \n \n \n Trial Registration<\/jats:bold>\n : Not applicable\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/ajco.70196","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:54:30Z","timestamp":1790567670000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Treatment Outcomes in Nasopharyngeal Carcinoma Treated With Intensity\u2010Modulated Radiotherapy Versus 3D\u2010Conformal Radiotherapy Techniques: A Single\u2010Center Experience in a Developing Country"],"prefix":"10.1111","author":[{"given":"Pooria","family":"Mousavi","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Cancer Institute IKHC Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Kazemian","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Institute IKHC Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ehsan","family":"Saraee","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center Cancer Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Aghili","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center Cancer Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ahmadi","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center Cancer Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasra","family":"Kolahdouzan","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center Cancer Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farshid","family":"Farhan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Institute IKHC Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amirhossein","family":"Ghasembagloo","sequence":"additional","affiliation":[{"name":"Medical School Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milad","family":"Payandeh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Cancer Institute IKHC Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Firouzifar","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farrokh","family":"Heidari","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology Research Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzieh","family":"Lashkari","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center Cancer Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Babaei","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center Cancer Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reza","family":"Ghalehtaki","sequence":"additional","affiliation":[{"name":"Radiation Oncology Research Center Cancer Research Institute Tehran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,27]]},"reference":[{"issue":"6","key":"e_1_2_15_2_1","first-page":"394","article-title":"Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"68","author":"Bray F.","year":"2018","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"7","key":"e_1_2_15_3_1","first-page":"323","article-title":"Global Cancer Observatory","volume":"23","author":"Ferlay J.","year":"2018","journal-title":"Cancer Today"},{"issue":"2","key":"e_1_2_15_4_1","first-page":"115","article-title":"Cancer Statistics in China, 2015","volume":"66","author":"Chen 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J.\u2010Y.","year":"2022","journal-title":"Therapeutic Advances in Medical Oncology"},{"key":"e_1_2_15_8_1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/B978-0-12-814403-9.00010-0","volume-title":"An Evidence\u2010Based Approach to the Management of Nasopharyngeal Cancer","author":"Ho F.","year":"2020"},{"issue":"1","key":"e_1_2_15_9_1","first-page":"E2130","article-title":"Evidence on Effectiveness of Intensity\u2010Modulated Radiotherapy versus 2\u2010Dimensional Radiotherapy in the Treatment of Nasopharyngeal Carcinoma: Meta\u2010Analysis and a Systematic Review of the Literature","volume":"38","author":"Co J.","year":"2016","journal-title":"Head & Neck"},{"issue":"1","key":"e_1_2_15_10_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.4103\/jcrt.jcrt_169_21","article-title":"Clinical Outcome of Intensity\u2010Modulated Radiotherapy versus Two\u2010Dimensional Conventional Radiotherapy in Locally Advanced Nasopharyngeal Carcinoma: Comparative Study at SKIMS Tertiary Care Institute","volume":"18","author":"Fatima K.","year":"2022","journal-title":"Journal of Cancer Research and Therapeutics"},{"issue":"10192","key":"e_1_2_15_11_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal Carcinoma","volume":"394","author":"Chen Y.\u2010P.","year":"2019","journal-title":"Lancet"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43163\u2010022\u201000212\u20102"},{"issue":"2","key":"e_1_2_15_13_1","first-page":"117","article-title":"Advances in Radiation Therapy: Conventional to 3D, to IMRT, to 4D, and Beyond","volume":"55","author":"Bucci M. K.","year":"2005","journal-title":"CA: A Cancer Journal for Clinicians"},{"issue":"33","key":"e_1_2_15_14_1","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1200\/JCO.20.02530","article-title":"Late Toxicity after Adjuvant Conventional Radiation versus Image\u2010Guided Intensity\u2010Modulated Radiotherapy for Cervical Cancer (PARCER): A Randomized Controlled Trial","volume":"39","author":"Chopra S.","year":"2021","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"e_1_2_15_15_1","first-page":"29","article-title":"Dosimetric Comparison: Intensity Modulated Radiation Therapy vs. 3D Conformal Radiotherapy in Prostate Cancer Radical Treatment","volume":"23","author":"Maric S.","year":"2022","journal-title":"Experimental and Applied Biomedical Research (EABR)"},{"issue":"1","key":"e_1_2_15_16_1","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1186\/s12885-024-12078-z","article-title":"PErspective and Current Status of Radiotherapy Service in IRan (PERSIR)\u20101 Study: Assessment of Current External Beam Radiotherapy Facilities, Staff and Techniques Compared to the International Guidelines","volume":"24","author":"Saeedian A.","year":"2024","journal-title":"BMC Cancer"},{"issue":"24","key":"e_1_2_15_17_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000015951","article-title":"Oncologic Outcomes of IMRT versus CRT for Nasopharyngeal Carcinoma","volume":"98","author":"Luo M.\u2010S.","year":"2019","journal-title":"Medicine"},{"issue":"8","key":"e_1_2_15_18_1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/hed.20378","article-title":"Preservation of Quality of Life After Intensity\u2010Modulated Radiotherapy for Early\u2010Stage Nasopharyngeal Carcinoma: Results of a Prospective Longitudinal Study","volume":"28","author":"Mcmillan A. S.","year":"2006","journal-title":"Head & Neck"},{"issue":"3","key":"e_1_2_15_19_1","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.radonc.2004.11.004","article-title":"Intensity Modulated Radiotherapy for Head and Neck Cancer: Evidence for Preserved Salivary Gland Function","volume":"74","author":"Saarilahti K.","year":"2005","journal-title":"Radiotherapy and Oncology"},{"issue":"2","key":"e_1_2_15_20_1","doi-asserted-by":"crossref","first-page":"e213","DOI":"10.1016\/j.ijrobp.2011.12.040","article-title":"Can Intensity\u2010Modulated Radiotherapy Preserve Oral Health\u2010Related Quality of Life of Nasopharyngeal Carcinoma Patients?","volume":"83","author":"Pow E. H. N.","year":"2012","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"1","key":"e_1_2_15_21_1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.radonc.2007.07.009","article-title":"Dysphagia Disorders in Patients With Cancer of the Oropharynx Are Significantly Affected by the Radiation Therapy Dose to the Superior and Middle Constrictor Muscle: A Dose\u2010Effect Relationship","volume":"85","author":"Levendag P. C.","year":"2007","journal-title":"Radiotherapy and Oncology"},{"issue":"4","key":"e_1_2_15_22_1","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/j.ijrobp.2008.02.061","article-title":"Treatment Techniques and Site Considerations Regarding Dysphagia\u2010Related Quality of Life in Cancer of the Oropharynx and Nasopharynx","volume":"72","author":"Teguh D. N.","year":"2008","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"1","key":"e_1_2_15_23_1","first-page":"E1026","article-title":"Long\u2010Term Late Toxicities and Quality of Life for Survivors of Nasopharyngeal Carcinoma Treated With Intensity\u2010Modulated Radiotherapy Versus Non\u2010Intensity\u2010Modulated Radiotherapy","volume":"38","author":"Huang T. L.","year":"2016","journal-title":"Head & Neck"},{"issue":"3","key":"e_1_2_15_24_1","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0360-3016(00)01389-4","article-title":"Treatment Planning and Delivery of Intensity\u2010Modulated Radiation Therapy for Primary Nasopharynx Cancer","volume":"49","author":"Hunt M. A.","year":"2001","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"3","key":"e_1_2_15_25_1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.radonc.2012.08.013","article-title":"A Prospective, Randomized Study Comparing Outcomes and Toxicities of Intensity\u2010modulated Radiotherapy vs. conventional Two\u2010Dimensional Radiotherapy for the Treatment of Nasopharyngeal Carcinoma","volume":"104","author":"Peng G.","year":"2012","journal-title":"Radiotherapy and Oncology"},{"issue":"3","key":"e_1_2_15_26_1","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.ijrobp.2004.11.002","article-title":"Treatment Outcomes and Late Complications of 849 Patients With Nasopharyngeal Carcinoma Treated With Radiotherapy Alone","volume":"62","author":"Yeh S.\u2010A.","year":"2005","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"1","key":"e_1_2_15_27_1","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1038\/s41598-021-87170-6","article-title":"Radiation\u2010Induced Acute Injury of Intensity\u2010Modulated Radiotherapy versus Three\u2010Dimensional Conformal Radiotherapy in Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma: A Prospective Cohort Study","volume":"11","author":"Yao Z.","year":"2021","journal-title":"Scientific Reports"},{"issue":"1","key":"e_1_2_15_28_1","first-page":"E905","article-title":"Toxicity of Concomitant Cetuximab and Radiotherapy With or Without Initial Taxane\u2010Based Induction Chemotherapy in Locally Advanced Head and Neck Cancer","volume":"38","author":"Levy A.","year":"2016","journal-title":"Head & Neck"},{"issue":"1","key":"e_1_2_15_29_1","first-page":"E1481","article-title":"Prospective Randomized Controlled Trial to Compare 3\u2010Dimensional Conformal Radiotherapy to Intensity\u2010modulated Radiotherapy in Head and Neck Squamous Cell Carcinoma: Long\u2010term Results","volume":"38","author":"Ghosh\u2010Laskar S.","year":"2016","journal-title":"Head & Neck"},{"issue":"4","key":"e_1_2_15_30_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s00066-019-01534-6","article-title":"Improved Treatment Outcome and Lower Skin Toxicity With Intensity\u2010Modulated Radiotherapy vs. 3D Conventional Radiotherapy in Anal Cancer","volume":"196","author":"Sauter M.","year":"2020","journal-title":"Strahlentherapie und Onkologie"},{"issue":"25","key":"e_1_2_15_31_1","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1200\/JCO.2013.54.6309","article-title":"Phase III Randomized Trial of Induction Chemotherapy in Patients With N2 or N3 Locally Advanced Head and Neck Cancer","volume":"32","author":"Cohen E. E. W.","year":"2014","journal-title":"Journal of Clinical Oncology"},{"issue":"7","key":"e_1_2_15_32_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200137","article-title":"Systematic Review and Meta\u2010Analyses of Intensity\u2010Modulated Radiation Therapy versus Conventional Two\u2010Dimensional and\/or Three\u2010Dimensional Radiotherapy in Curative\u2010Intent Management of Head and Neck Squamous Cell Carcinoma","volume":"13","author":"Gupta T.","year":"2018","journal-title":"PLoS ONE"},{"issue":"6","key":"e_1_2_15_33_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00066-016-0959-y","article-title":"IMRT vs. 2D\u2010Radiotherapy or 3D\u2010Conformal Radiotherapy of Nasopharyngeal Carcinoma","volume":"192","author":"Moon S. H.","year":"2016","journal-title":"Strahlentherapie und Onkologie"},{"issue":"8","key":"e_1_2_15_34_1","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1007\/s00432-017-2401-y","article-title":"A Retrospective Study Comparing the Outcomes and Toxicities of Intensity\u2010Modulated Radiotherapy versus Two\u2010Dimensional Conventional Radiotherapy for the Treatment of Children and Adolescent Nasopharyngeal Carcinoma","volume":"143","author":"Qiu W.\u2010Z.","year":"2017","journal-title":"Journal of Cancer Research and Clinical Oncology"},{"issue":"3","key":"e_1_2_15_35_1","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ijrobp.2010.03.024","article-title":"How Does Intensity\u2010Modulated Radiotherapy versus Conventional Two\u2010Dimensional Radiotherapy Influence the Treatment Results in Nasopharyngeal Carcinoma Patients?","volume":"80","author":"Lai S.\u2010Z.","year":"2011","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"6","key":"e_1_2_15_36_1","first-page":"7773","article-title":"Application of Intensity\u2010Modulated Radiation Therapy in the Treatment of Nasopharyngeal Carcinoma","volume":"14","author":"Yan H.","year":"2017","journal-title":"Oncology Letters"},{"issue":"12","key":"e_1_2_15_37_1","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.3390\/cancers11121996","article-title":"Patterns of Care and Outcomes of Intensity\u2010Modulated Radiotherapy and 3D Conformal Radiotherapy for Early Stage Glottic Cancer: A National Cancer Database Analysis","volume":"11","author":"Korpics M. C.","year":"2019","journal-title":"Cancers"},{"issue":"2","key":"e_1_2_15_38_1","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.18632\/oncotarget.13830","article-title":"Dosimetric Evaluation of the Skin\u2010Sparing Effects of 3\u2010Dimensional Conformal Radiotherapy and Intensity\u2010Modulated Radiotherapy for Left Breast Cancer","volume":"8","author":"Jo I. Y.","year":"2017","journal-title":"Oncotarget"},{"key":"e_1_2_15_39_1","doi-asserted-by":"crossref","first-page":"6285","DOI":"10.2147\/CMAR.S195989","article-title":"Correlation Between Pelvic Bone Marrow Radiation Dose and Acute Hematological Toxicity in Cervical Cancer Patients Treated With Concurrent Chemoradiation","volume":"11","author":"Kumar T.","year":"2019","journal-title":"Cancer Management and Research"},{"issue":"2","key":"e_1_2_15_40_1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.ijrobp.2007.12.054","article-title":"Quality of Life and Survival Outcome for Patients with Nasopharyngeal Carcinoma Receiving Three\u2010Dimensional Conformal Radiotherapy vs. Intensity\u2010Modulated Radiotherapy\u2014A Longitudinal Study","volume":"72","author":"Fang F.\u2010M.","year":"2008","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"3","key":"e_1_2_15_41_1","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.radonc.2014.02.003","article-title":"Evolution of Treatment for Nasopharyngeal Cancer\u2014Success and Setback in the Intensity\u2010modulated Radiotherapy Era","volume":"110","author":"Lee A. W. M.","year":"2014","journal-title":"Radiotherapy and Oncology"},{"issue":"2","key":"e_1_2_15_42_1","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11912-003-0100-0","article-title":"Intensity\u2010Modulated Radiotherapy for Carcinoma of the Head and Neck","volume":"5","author":"Pe\u00f1agar\u00edcano J. A.","year":"2003","journal-title":"Current Oncology Reports"},{"issue":"4","key":"e_1_2_15_43_1","first-page":"241","article-title":"Comparisons of Quality of Life for Patients With Nasopharyngeal Carcinoma After Treatment With Different RT Technologies","volume":"34","author":"Jang\u2010Chun L.","year":"2014","journal-title":"Acta Otorhinolaryngologica Italica"},{"issue":"2","key":"e_1_2_15_44_1","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1001\/jamaoto.2013.5988","article-title":"Quality of Life Among Long\u2010Term Survivors of Head and Neck Cancer Treated by Intensity\u2010Modulated Radiotherapy","volume":"140","author":"Chen A. M.","year":"2014","journal-title":"JAMA Otolaryngology\u2013Head & Neck Surgery"},{"issue":"5","key":"e_1_2_15_45_1","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.ijrobp.2006.11.012","article-title":"Impact of Intensity\u2010Modulated Radiotherapy on Health\u2010Related Quality of Life for Head and Neck Cancer Patients: Matched\u2010pair Comparison With Conventional Radiotherapy","volume":"67","author":"Graff P.","year":"2007","journal-title":"International Journal of Radiation Oncology*Biology*Physics"},{"issue":"2","key":"e_1_2_15_46_1","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/cncr.22396","article-title":"Intensity\u2010Modulated or Conformal Radiotherapy Improves the Quality of Life of Patients With Nasopharyngeal Carcinoma","volume":"109","author":"Fang F.\u2010M.","year":"2007","journal-title":"Cancer"},{"issue":"3","key":"e_1_2_15_47_1","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijrobp.2005.02.045","article-title":"Matched Case\u2013Control Study of Quality of Life and Xerostomia After Intensity\u2010Modulated Radiotherapy or Standard Radiotherapy for Head\u2010and\u2010Neck Cancer: Initial Report","volume":"63","author":"Jabbari S.","year":"2005","journal-title":"International Journal of Radiation Oncology*Biology*Physics"}],"container-title":["Asia-Pacific Journal of Clinical Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70196","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/ajco.70196","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajco.70196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:54:38Z","timestamp":1790567678000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajco.70196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,27]]},"references-count":46,"alternative-id":["10.1111\/ajco.70196"],"URL":"https:\/\/doi.org\/10.1111\/ajco.70196","archive":["Portico"],"relation":{},"ISSN":["1743-7555","1743-7563"],"issn-type":[{"value":"1743-7555","type":"print"},{"value":"1743-7563","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,27]]},"assertion":[{"value":"2026-05-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"ajco.70196"}}