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Malignancy is a recognised association, although colorectal cancer remains an uncommon underlying cause. We report a 68\u2010year\u2010old woman with sigmoid adenocarcinoma who developed severe postoperative haemoperitoneum associated with progressive activated partial thromboplastin time prolongation, an initial FVIII activity of 52\u00a0IU\/dL that subsequently declined to 2\u00a0IU\/dL, and development of an FVIII inhibitor measuring 9.7 BU. The case highlights diagnostic challenges associated with AHA, particularly the risk of delayed diagnosis and the complexities of balancing immunosuppressive intensity alongside haemostatic therapy. We then present a review of current literature to guide management for this rare condition and emerging therapies.<\/jats:p>","DOI":"10.1111\/ajco.70202","type":"journal-article","created":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:05:38Z","timestamp":1791349538000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Rare Case of Acquired Haemophilia A Following Sigmoid Adenocarcinoma: Case Report and Literature Review"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-508X","authenticated-orcid":false,"given":"Benjamin","family":"Reardon","sequence":"first","affiliation":[{"name":"School of Medicine and Public Health Joint Medical Program University of Newcastle  Newcastle Australia"},{"name":"Haematology Department Calvary Mater Hospital Newcastle  Newcastle Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harini","family":"Haran","sequence":"additional","affiliation":[{"name":"Haematology Department Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology Westmead Hospital  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Curnow","sequence":"additional","affiliation":[{"name":"Haematology Department Institute of Clinical Pathology and Medical Research (ICPMR), NSW Health Pathology Westmead Hospital  Sydney Australia"},{"name":"Westmead Clinical School University of Sydney  Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2019.230771"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538\u20107836.2012.04654.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32832ca388"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100029\u20101245109"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000005232"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102006\u201006\u2010029850"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24777"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(20010315)91:6<1067::AID\u2010CNCR1101>3.0.CO;2\u20104"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102008\u201003\u2010143586"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185\u2010009\u20100347\u20109"},{"issue":"2","key":"e_1_2_7_12_1","first-page":"286","article-title":"Acquired Haemophilia as the Initial Manifestation of Colorectal Cancer Recurrence","volume":"81","author":"Villalba N. 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