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Successful treatment of acne can improve the quality of life and reduce levels of anxiety and depression in these individuals. The current treatment of choice for severe or refractive acne is isotretinoin, a retinoid. While the possible causal association between isotretinoin and mental illness remains a controversial topic, a recent systematic review has presented evidence to support this relationship. In light of this evidence, a group of dermatologists and psychiatrists have collaborated to develop these recommendations to aid the safe prescribing of isotretinoin in adolescents. These clinical suggestions are aimed at practitioners in both disciplines to increase awareness of the current evidence in support of the association between isotretinoin and adolescent depression.<\/jats:p>","DOI":"10.1111\/ajd.12117","type":"journal-article","created":{"date-parts":[[2013,11,28]],"date-time":"2013-11-28T04:45:04Z","timestamp":1385613904000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Isotretinoin and mental health in adolescents: Australian consensus"],"prefix":"10.1111","volume":"55","author":[{"given":"Casey","family":"Rowe","sequence":"first","affiliation":[{"name":"University of Queensland Centre for Clinical Research  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Spelman","sequence":"additional","affiliation":[{"name":"Queensland Institute of Dermatology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Oziemski","sequence":"additional","affiliation":[{"name":"Morris Towers  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Ryan","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research  Brisbane Queensland Australia"},{"name":"Queensland Centre for Mental Health Research  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobhan","family":"Manoharan","sequence":"additional","affiliation":[{"name":"Westside Dermatology  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry","family":"Wilson","sequence":"additional","affiliation":[{"name":"Toowoomba Skin and Eye Clinic  Toowoomba Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Daubney","sequence":"additional","affiliation":[{"name":"Griffith University Logan Campus  Logan City Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Scott","sequence":"additional","affiliation":[{"name":"University of Queensland Centre for Clinical Research  Brisbane Queensland Australia"},{"name":"Metro North Mental Health Royal Brisbane and Women's Hospital  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2013,11,28]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000066582"},{"key":"e_1_2_6_3_1","first-page":"133","article-title":"The interaction between acne vulgaris and the psyche","volume":"70","author":"Baldwin HE","year":"2002","journal-title":"Cutis"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1418"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1473-2165.2010.00478.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2006.00979.x"},{"key":"e_1_2_6_7_1","first-page":"33","article-title":"An update on the presence of psychiatric comorbidities in acne patients, Part 1: overview of prevalence","volume":"88","author":"Saitta P","year":"2011","journal-title":"Cutis"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.264"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02511.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10060.x"},{"issue":"4","key":"e_1_2_6_11_1","first-page":"3","article-title":"Psychosocial effects of acne","volume":"8","author":"Thomas DR","year":"2004","journal-title":"J. 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