{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T20:50:36Z","timestamp":1774126236105,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T00:00:00Z","timestamp":1392768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Austrian Society of Dermatology and Venerology","award":["non-restricted fund"],"award-info":[{"award-number":["non-restricted fund"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Elevated serum tryptase levels can be a sign of mastocytosis, which is a rare disease associated with systemic and\/or skin manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate patients with elevated tryptase levels in regard to their underlying diseases, and to determine whether increased tryptase can be used as a diagnostic marker for underlying mastocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a retrospective study the data of 96 patients with serum tryptase levels higher than 15\u2009\u03bcg\/L were systematically analysed. In 48 patients control investigations for baseline tryptase were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010three of the 96 patients had tryptase levels \u226520\u2009\u03bcg\/L. A mere 16% of the 96 patients suffered from mastocytosis and had the highest tryptase levels (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). The remaining patients had anaphylaxis (36%), urticaria and angioedema (26%), local reactions to insect bites (4%), drug reactions (3%), or miscellaneous diagnoses (15%). Only 16 of these had acute symptoms at tryptase investigation. In all, 48 patients had a follow up; in 7\/48 patients with acute symptoms normal tryptase levels were seen at control investigations, but 41\/48 (85%) patients showed continuously elevated tryptase levels &gt;15\u2009\u03bcg\/L and in 30 patients (62%) even values &gt;20\u2009\u03bcg\/L; 11 of these patients had anaphylaxis, five urticaria, five other diagnoses and nine patients mastocytosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More than 50% of patients with non\u2010mastocytosis such as urticaria and angioedema, drug or anaphylactic reactions repeatedly had tryptase levels higher than 20\u2009\u03bcg\/L. Since baseline tryptase &gt;20\u2009\u03bcg\/L is a minor criterion for mastocytosis, these patients should be inspected for skin lesions of mastocytosis and receive a diagnostic body work\u2010up for systemic mastocytosis including a bone marrow biopsy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12146","type":"journal-article","created":{"date-parts":[[2014,2,19]],"date-time":"2014-02-19T11:09:19Z","timestamp":1392808159000},"page":"7-13","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Disease spectrum in patients with elevated serum tryptase levels"],"prefix":"10.1111","volume":"56","author":[{"given":"Elisabeth","family":"Aberer","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Savic","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnes","family":"Bretterklieber","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Reiter","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Berghold","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics, Statistics and Documentation Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Aberer","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology Medical University of Graz Graz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,2,19]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1845","volume-title":"Dermatology","author":"Tharp MD","year":"2008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03251.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000092556"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.026"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03582.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2007.01807.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2010.07482_supp.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.08.035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01569.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2006.05.010"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.08.027"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.04.025"},{"key":"e_1_2_7_14_1","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1111\/j.1365-2222.2007.02804.x","article-title":"Prevalence of allergy and anaphylactic symptoms in 210 adult and pediatric patients with mastocytosis in Spain: a study of the Spanish network on mastocytosis (REMA)","volume":"37","author":"Olano DG","year":"2007","journal-title":"Clin. 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