{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:13:38Z","timestamp":1787876018520,"version":"build-2784847793"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T00:00:00Z","timestamp":1394668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2014,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Questions have been raised as to whether propranolol, which crosses the blood\u2010brain barrier, when used early in life may have an adverse effect on gross motor development. A retrospective survey asking questions about gross motor development was sent to the families of children who had been prescribed oral propranolol for infantile haemangioma at <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>ydney Children's Hospital between 2008 and 2013. It was found that of the 84 patients surveyed, four were delayed in walking unassisted. There was a statistically significant influence if the child was taking other medications which included prednisolone, vincristine, omeprazole, ranitidine, salbutamol, Flixotide, Timoptol and antibiotics. This was not further analysed in this study because of the low numbers involved. There was no statistically significant influence of gestational age, birth weight or length of time on propranolol. This study adds to the retrospective data available; however large\u2010scale prospective studies are needed to identify unexpected long\u2010term side\u2010effects.<\/jats:p>","DOI":"10.1111\/ajd.12156","type":"journal-article","created":{"date-parts":[[2014,3,14]],"date-time":"2014-03-14T03:08:55Z","timestamp":1394766535000},"page":"209-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Retrospective follow up of gross motor development in children using propranolol for treatment of infantile haemangioma at <scp>S<\/scp>ydney Children's Hospital"],"prefix":"10.1111","volume":"55","author":[{"given":"Kate","family":"Gonski","sequence":"first","affiliation":[{"name":"Prince of Wales Hospital  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orli","family":"Wargon","sequence":"additional","affiliation":[{"name":"Sydney Children's Hospital  Sydney New South Wales Australia"},{"name":"School of Women's and Children's Health University of New South Wales  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"key":"e_1_2_3_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-010-1324-2"},{"key":"e_1_2_3_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2008.00626.x"},{"key":"e_1_2_3_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/850193"},{"key":"e_1_2_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200307000-00032"},{"key":"e_1_2_3_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12436"},{"key":"e_1_2_3_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc0708819"},{"key":"e_1_2_3_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2012.02521.x"},{"key":"e_1_2_3_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/archfacial.2011.33"},{"key":"e_1_2_3_10_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-0029"},{"key":"e_1_2_3_11_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/j.1651-2227.2006.tb02379.x","article-title":"WHO Motor Development Study: windows of achievement for six gross motor development milestones","volume":"450","author":"WHO Multicentre Growth Reference Study Group","year":"2006","journal-title":"Acta Paediatr."}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12156","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,4]],"date-time":"2023-10-04T22:39:36Z","timestamp":1696459176000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,13]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["10.1111\/ajd.12156"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12156","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,13]]},"assertion":[{"value":"2013-12-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}