{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:01:17Z","timestamp":1784246477855,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Cutaneous metastases occur in up to 10% of all visceral malignancies. This study aims to determine the clinico\u2010epidemiological characteristics of patients diagnosed with cutaneous metastases at a leading Asian tertiary dermatological centre.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective chart review was carried out on all patients diagnosed with cutaneous metastases from 2001 to 2010, identified through the <jats:styled-content style=\"fixed-case\">N<\/jats:styled-content>ational <jats:styled-content style=\"fixed-case\">S<\/jats:styled-content>kin <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>entre's clinical and histological databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all, 35 patients were diagnosed with cutaneous metastases at a mean age of 65 years, with a female: male ratio of 3:2 and with most (97%) being <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>hinese. Cutaneous metastases were the first presentation of cancer in 34% of patients (<jats:italic>n<\/jats:italic>\u2009=\u200912). The two commonest primaries were breast (49%, <jats:italic>n<\/jats:italic>\u2009=\u200917) and lung (9%, <jats:italic>n<\/jats:italic>\u2009=\u20093). Most had cutaneous metastases on the chest (37%, <jats:italic>n<\/jats:italic>\u2009=\u200913) followed by the pelvis (17%, <jats:italic>n<\/jats:italic>\u2009=\u20096) and 20% (<jats:italic>n<\/jats:italic>\u2009=\u20097) had skin lesions on multiple sites. Clinically, 46% of patients (<jats:italic>n<\/jats:italic>\u2009=\u200916) presented with nodule(s), 26% (<jats:italic>n<\/jats:italic>\u2009=\u20099) with plaque(s) and 20% (<jats:italic>n<\/jats:italic>\u2009=\u20097) with heterogeneous morphologies. Cutaneous metastases were suspected in 72% of patients (<jats:italic>n<\/jats:italic>\u2009=\u200925), attributed to clinical features (46%, <jats:italic>n<\/jats:italic>\u2009=\u200916) or the presence of active metastatic disease elsewhere (26%, <jats:italic>n<\/jats:italic>\u2009=\u20099). All lesions appeared dermal in origin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cutaneous metastases are highly variable in presentation and a high index of suspicion is required for prompt diagnosis, especially in patients with a history of cancer, regardless of stage of treatment of the primary tumour.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12194","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T13:21:10Z","timestamp":1409577670000},"page":"1-6","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["A retrospective review of cutaneous metastases at the <scp>N<\/scp>ational <scp>S<\/scp>kin <scp>C<\/scp>entre <scp>S<\/scp>ingapore"],"prefix":"10.1111","volume":"56","author":[{"given":"Emily Yiping","family":"Gan","sequence":"first","affiliation":[{"name":"National Skin Centre  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin Tze\u2010Wei","family":"Chio","sequence":"additional","affiliation":[{"name":"National Skin Centre  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wee Ping","family":"Tan","sequence":"additional","affiliation":[{"name":"National Skin Centre  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(90)70002-Y"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.SMJ.0000053676.73249.E5"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01364.x"},{"key":"e_1_2_5_5_1","first-page":"7","article-title":"Canadian trends in cancer prevalence","volume":"23","author":"Ellison LF","year":"2012","journal-title":"Health Rep."},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2012.44.1.11"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25516"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1469"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010606623499"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(92)70146-7"},{"key":"e_1_2_5_11_1","volume-title":"TNM Classification of Malignant Tumours","author":"Sobin LH","year":"2009"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70173-Q"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02590.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.5.613"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.60548"},{"key":"e_1_2_5_16_1","first-page":"167","article-title":"Cutaneous metastases from internal cancers","volume":"17","author":"Benmously R","year":"2008","journal-title":"Acta Dermatovenerol. Alp. Panonica Adriat."},{"key":"e_1_2_5_17_1","first-page":"3","article-title":"Singapore cancer trends in the last decade","volume":"53","author":"Lim GH","year":"2012","journal-title":"Singapore Med. J."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003251"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr1306"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930230311"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31823069cf"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1972.01620090034008"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870315)59:6<1184::AID-CNCR2820590625>3.0.CO;2-K"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1999.00423.x"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910615)67:12<3087::AID-CNCR2820671225>3.0.CO;2-D"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(09)80086-8"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.10.007"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2009.01469.x"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12194","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12194","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T12:09:55Z","timestamp":1695470995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["10.1111\/ajd.12194"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12194","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"2013-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2014-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}