{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T17:41:13Z","timestamp":1785865273420,"version":"3.56.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T00:00:00Z","timestamp":1408406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>The catalase (<jats:italic><jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content><\/jats:italic>) <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content> at codon 389\u2009in the exon 9 polymorphism has been implicated in susceptibility to vitiligo but a large number of studies have reported inconclusive results. The purpose of this study is to evaluate the association between the catalase gene polymorphism (389<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content>) and the risk of vitiligo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A meta\u2010analysis was carried out to analyse the association between 389<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> and vitiligo risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight case\u2010control studies with 2923 cases and 4237 controls were included in the meta\u2010analysis. The results indicated that there was no association between this polymorphism and vitiligo (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.08, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20090.98\u20131.20, <jats:italic>P<\/jats:italic>\u2009=\u20090.11, <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.07, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20090.99\u20131.16, <jats:italic>P<\/jats:italic>\u2009=\u20090.092). In a subgroup analysis by ethnicity, no significant association between the <jats:italic><jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content><\/jats:italic> gene 389<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> polymorphism and vitiligo susceptibility was found in <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>aucasians (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.15, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20090.98\u20131.35, <jats:italic>P<\/jats:italic>\u2009=\u20090.08; <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.07, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20090.97\u20131.19, <jats:italic>P<\/jats:italic>\u2009=\u20090.173) and <jats:styled-content style=\"fixed-case\">A<\/jats:styled-content>sians (<jats:styled-content style=\"fixed-case\">TT<\/jats:styled-content>\u2009+\u2009<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.12, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> =0.93\u20131.34, <jats:italic>P<\/jats:italic>\u2009=\u20090.23; <jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> versus <jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>: <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u2009=\u20091.07, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u2009=\u20090.94\u20131.21, <jats:italic>P<\/jats:italic>\u2009=\u20090.321).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that 389<jats:styled-content style=\"fixed-case\">C<\/jats:styled-content>&gt;<jats:styled-content style=\"fixed-case\">T<\/jats:styled-content> may not contribute to vitiligo susceptibility. However, larger primary studies with the consideration of gene\u2013environment and gene\u2013gene interactions are still required to further evaluate the interaction of <jats:italic><jats:styled-content style=\"fixed-case\">CAT<\/jats:styled-content><\/jats:italic> gene polymorphism with vitiligo susceptibility.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12204","type":"journal-article","created":{"date-parts":[[2014,8,20]],"date-time":"2014-08-20T03:43:13Z","timestamp":1408506193000},"page":"180-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Lack of association between the 389<scp>C<\/scp>&gt;<scp>T<\/scp> polymorphism (rs769217) in the catalase (<i><scp>CAT<\/scp><\/i>) gene and the risk of vitiligo: An update by meta\u2010analysis"],"prefix":"10.1111","volume":"56","author":[{"given":"Jie","family":"He","sequence":"first","affiliation":[{"name":"First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunhui","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bocheng","family":"Ren","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Sun","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wancheng","family":"Li","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Chengdu Medical College  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,8,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2012.712113"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.48427"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.192"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2012.12005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1179\/1351000212Y.0000000025"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2004.01080.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-197137"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.4238\/2011.October.31.12"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03260057"},{"key":"e_1_2_6_11_1","first-page":"e173","article-title":"No association between catalase (CAT) gene polymorphisms and susceptibility to vitiligo in a Turkish population","volume":"164","author":"Akbas H","year":"2013","journal-title":"Clin. 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