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In this report we describe patterns of onset, regrowth and relapse in <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> and propose potential underlying mechanisms. We believe that these aspects of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> require integration into modern theories of <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> pathogenesis.<\/jats:p>","DOI":"10.1111\/ajd.12227","type":"journal-article","created":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T14:35:05Z","timestamp":1409582105000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical observations in alopecia areata: Implications and hypotheses"],"prefix":"10.1111","volume":"57","author":[{"given":"Jane","family":"Li","sequence":"first","affiliation":[{"name":"Department of Medicine (Dermatology) St Vincent's Hospital  Melbourne Victoria Australia"},{"name":"Department of Microbiology and Immunology Peter Doherty Institute for Infection and Immunity University of Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rod","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Medicine (Dermatology) St Vincent's Hospital  Melbourne Victoria Australia"},{"name":"Department of Dermatology Epworth Hospital  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,9]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1103442"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1968.tb11960.x"},{"key":"e_1_2_13_4_1","first-page":"66.1","volume-title":"Rook's Textbook of Dermatology","author":"Messenger AG","year":"2010"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(19970815)38:4<443::AID-JEMT12>3.0.CO;2-J"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12065"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb06058.x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.134.8.1042"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.072564mp"},{"key":"e_1_2_13_10_1","first-page":"93","article-title":"Common hair loss disorders","volume":"68","author":"Springer K","year":"2003","journal-title":"Am. 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