{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:48:57Z","timestamp":1791287337251,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T00:00:00Z","timestamp":1415059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Janssen-Cilag Malaysia"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"Abstract<\/jats:title>An objective tool to quantify treatment response in vitiligo is currently lacking. This study aimed to objectively evaluate the treatment response in vitiligo by using a computerised digital imaging analysis system (C<\/jats:styled-content>\u2010DIAS<\/jats:styled-content>) and to compare it with the p<\/jats:styled-content>hysician's g<\/jats:styled-content>lobal a<\/jats:styled-content>ssessment (PGA<\/jats:styled-content>). Tacrolimus ointment 0.1% (P<\/jats:styled-content>rotopic; Astellas Pharma Tech,Toyama, Japan) was applied twice daily on selected lesions which were photographed every 6 weeks for 24 weeks. The primary efficacy end\u2010point was the mean percentage of repigmentation (MPR<\/jats:styled-content>), as assessed by the digital method (MPR<\/jats:styled-content>\u2010C<\/jats:styled-content>\u2010DIAS<\/jats:styled-content>) or by the PGA<\/jats:styled-content>. The response was categorised into none (0%), mild (1\u201325%), moderate (26\u201350%), good (51\u201375%) and excellent (76\u2013100%). MPR<\/jats:styled-content>\u2010C<\/jats:styled-content>\u2010DIAS<\/jats:styled-content>: Out of 56 patients, 44 (79%) responded. Overall, the response was mild in 22 (39%), moderate in 21(40%) and good in one (2%) patient(s). A total of 39 (70%) patients responded as measured by PGA<\/jats:styled-content>. The repigmentation was mild in 27(48%), moderate in 10 (18%) and good to excellent in two (4%) patients. The \u03ba test of consistency was 0.17 (P<\/jats:italic>\u2009=\u20090.053), which shows poor agreement between the two assessment methods, although this is not statistically significant. The C<\/jats:styled-content>\u2010DIAS<\/jats:styled-content> can be used to perform an objective analysis of repigmentation or depigmentation in vitiligo skin lesions in response to treatment.<\/jats:p>","DOI":"10.1111\/ajd.12247","type":"journal-article","created":{"date-parts":[[2014,11,4]],"date-time":"2014-11-04T12:26:21Z","timestamp":1415103981000},"page":"285-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Objective assessment of vitiligo with a computerised digital imaging analysis system"],"prefix":"10.1111","volume":"56","author":[{"given":"Norashikin","family":"Shamsudin","sequence":"first","affiliation":[{"name":"Dermatology Unit Department of Medicine Faculty of Medicine and Health Sciences Universiti Putra Malaysia Kuala Lumpur Perak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraiya H","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Kuala Lumpur Kuala Lumpur Perak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermawan","family":"Nugroho","sequence":"additional","affiliation":[{"name":"Intelligent Signal and Imaging Research Department of Electrical and Electronic Engineering Universiti Teknologi Petronas Tronoh Perak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Hani","family":"Ahmad Fadzil","sequence":"additional","affiliation":[{"name":"Intelligent Signal and Imaging Research Department of Electrical and Electronic Engineering Universiti Teknologi Petronas Tronoh Perak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-1-58"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.293.6.730"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04505.x"},{"key":"e_1_2_6_5_1","first-page":"150","article-title":"A new digital image analysis system useful for surface assessment of vitiligo lesions in transplantation studies","volume":"14","author":"Van Geel N","year":"2004","journal-title":"Eur. 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