{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T07:21:44Z","timestamp":1744183304260},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T00:00:00Z","timestamp":1429488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"a grant from the Itoe Okamoto Scientific Award, SHISEIKAI"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cause of perioral dermatitis is still unknown. We previously reported that rod\u2010shaped bacteria (<jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content>) containing intracellular granules were detected in cases of perioral dermatitis at a high incidence. The aim of this study was to study further the role of <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> in perioral dermatitis. Altogether 10 patients with perioral dermatitis and eight patients with perioral corticosteroid\u2010induced rosacea, who were referred to our department from 2009 to 2014, were examined for the presence of <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content>, using the tape\u2010stripping toluidine blue method. <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> were detected on the surfaces of the roots of vellus hairs from lesions in nine of the 10 patients with perioral dermatitis. In contrast, <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> were not detected in any of the eight patients with perioral corticosteroid\u2010induced rosacea. No <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> were found in the perioral areas of other types of facial dermatitis, including atopic dermatitis and seboerrheic dermatitis or in 16 healthy controls. We treated four of the patients with perioral dermatitis with minocycline hydrochloride and five with cefcapene pivoxil hydrochloride hydrate. Three of the patients with perioral dermatitis who were treated with minocycline hydrochloride were cured in 3 to 8 weeks, while the five patients treated with cefcapene pivoxil hydrochloride hydrate were cured in 2 to 9 weeks. These results strongly suggest that <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content> (possible <jats:italic>fusobacteria<\/jats:italic>) play an important role in perioral dermatitis and that this is probably a distinct clinical entity from corticosteroid\u2010induced rosacea. Cefcapene pivoxil hydrochloride hydrate seems to be an effective treatment for perioral dermatitis associated with <jats:styled-content style=\"fixed-case\">RB<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ajd.12344","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T07:27:07Z","timestamp":1429514827000},"page":"225-228","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The pathogenetic role of rod\u2010shaped bacteria containing intracellular granules in the vellus hairs of a patient with perioral dermatitis: A comparison with perioral corticosteroid\u2010induced rosacea"],"prefix":"10.1111","volume":"57","author":[{"given":"Azusa","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Ishiguro","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Women's Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"11","volume-title":"Rook's Textbook of Dermatology","author":"Berth\u2010Jones J","year":"2010"},{"key":"e_1_2_7_3_1","first-page":"359","article-title":"A study of pathogenetic role of fusobacteria for perioral dermatitis","volume":"52","author":"Ishiguro N","year":"2010","journal-title":"Rinsho Derma"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2012.757284"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1994.tb00407.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-002-1026-5"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.2003.01349.x"},{"key":"e_1_2_7_8_1","first-page":"433","article-title":"Zum Nachweis von Fusobakterien aus Effloreszenzen der perioralen dermatitis","volume":"22","author":"Buck A","year":"1971","journal-title":"Hautarzt"},{"key":"e_1_2_7_9_1","first-page":"74","article-title":"Zur pathogenese der perioralen Dermatitis","volume":"28","author":"Kalkoff KW","year":"1977","journal-title":"Hautarzt"},{"key":"e_1_2_7_10_1","first-page":"903","article-title":"Perioral dermatitis: etiology and treatment","volume":"17","author":"Bendl BJ","year":"1976","journal-title":"Cutis"},{"key":"e_1_2_7_11_1","first-page":"433","article-title":"Evidence based review of perioral dermatitis therapy","volume":"145","author":"Hall CS","year":"2010","journal-title":"G. Ital. Dermatol. Venereol."}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12344","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12344","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:52:47Z","timestamp":1695570767000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ajd.12344"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12344","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]},"assertion":[{"value":"2015-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-03-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}