{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T22:01:17Z","timestamp":1761948077594,"version":"3.37.3"},"reference-count":71,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,25]],"date-time":"2015-05-25T00:00:00Z","timestamp":1432512000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cutaneous melanoma is a heterogeneous disease affecting the regulation of multiple genes and proteins that contribute to melanoma progression. Survival for patients with locally invasive disease varies greatly, even within tumour stages based on current prognostic criteria. This has prompted investigations into the value of additional clinical or biological parameters predicting survival. In particular, the improved knowledge of tumour biology has fed the hope that the outcome may be predicted at the molecular level. The prognostic value of numerous potential biomarkers has therefore been evaluated in protein and gene expression studies, and genomic associations with melanoma prognosis are beginning to emerge. These potential biomarkers interrogate key tumour and host processes important for tumour development and progression, such as proliferation, invasion and migration through epithelial mesenchymal transition or the host immune or vascular responses. This research may allow more individualised information on prognosis if the challenges regarding the quality and validation of studies are overcome.<\/jats:p>","DOI":"10.1111\/ajd.12348","type":"journal-article","created":{"date-parts":[[2015,5,26]],"date-time":"2015-05-26T02:33:09Z","timestamp":1432607589000},"page":"175-181","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical and biological determinants of melanoma progression: Should all be considered for clinical management?"],"prefix":"10.1111","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4705-5204","authenticated-orcid":false,"given":"Casey J","family":"Rowe","sequence":"first","affiliation":[{"name":"Translational Research Institute UQ Diamantina Institute University of Queensland  Woolloongabba Queensland Australia"},{"name":"University of Queensland Centre for Clinical Research University of Queensland  Herston Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiarash","family":"Khosrotehrani","sequence":"additional","affiliation":[{"name":"Translational Research Institute UQ Diamantina Institute University of Queensland  Woolloongabba Queensland Australia"},{"name":"University of Queensland Centre for Clinical Research University of Queensland  Herston Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,25]]},"reference":[{"volume-title":"Cancer in Australia: An Overview 2012","year":"2012","author":"Australian Institute of Health and Welfare, Australasian Association of Cancer Registries","key":"e_1_2_4_2_1"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2008.09.001"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09299.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.08.1463"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.8561"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.12.015"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-2538"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.16.3635"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.2217\/fon.13.245"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.354"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.0584"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.4408"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2011.06.048"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-2977-7"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950515)75:10<2492::AID-CNCR2820751015>3.0.CO;2-W"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcms.2013.09.007"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(89)90261-7"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1024-4"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.3002"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.37.8539"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04181.x"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.9852"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2013.4581"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13144"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.8.1013"},{"key":"e_1_2_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81683-9"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dji237"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1586\/epr.12.5"},{"key":"e_1_2_4_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.958"},{"key":"e_1_2_4_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10350.x"},{"key":"e_1_2_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(84)80310-X"},{"key":"e_1_2_4_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1993.60"},{"key":"e_1_2_4_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djp038"},{"key":"e_1_2_4_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0901"},{"key":"e_1_2_4_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.0735"},{"key":"e_1_2_4_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10685"},{"key":"e_1_2_4_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi200642e"},{"key":"e_1_2_4_40_1","doi-asserted-by":"publisher","DOI":"10.4103\/1477-3163.62141"},{"key":"e_1_2_4_41_1","first-page":"1845","article-title":"Loss of nuclear p16 protein expression correlates with increased tumor cell proliferation (Ki\u201067) and poor prognosis in patients with vertical growth phase melanoma","volume":"6","author":"Straume O","year":"2000","journal-title":"Clin. Cancer Res."},{"key":"e_1_2_4_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70269-3"},{"key":"e_1_2_4_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.06.009"},{"key":"e_1_2_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.10.064"},{"key":"e_1_2_4_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086194"},{"key":"e_1_2_4_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju246"},{"key":"e_1_2_4_47_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229259"},{"key":"e_1_2_4_48_1","first-page":"328","article-title":"PARP\u20101 and PARP\u20102: new players in tumour development","volume":"1","author":"Yelamos J","year":"2011","journal-title":"Am. J. Cancer Res."},{"key":"e_1_2_4_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087057"},{"key":"e_1_2_4_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28796"},{"key":"e_1_2_4_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29280"},{"key":"e_1_2_4_52_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_4_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10824.x"},{"key":"e_1_2_4_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12343"},{"key":"e_1_2_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.08.018"},{"key":"e_1_2_4_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0731"},{"key":"e_1_2_4_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.305"},{"key":"e_1_2_4_58_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2980"},{"key":"e_1_2_4_59_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-13-0215"},{"key":"e_1_2_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2011.09.007"},{"key":"e_1_2_4_61_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.12.8745"},{"key":"e_1_2_4_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3216"},{"key":"e_1_2_4_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-11-43"},{"key":"e_1_2_4_64_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.9919"},{"key":"e_1_2_4_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12688"},{"key":"e_1_2_4_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64922-X"},{"key":"e_1_2_4_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.01.009"},{"key":"e_1_2_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2014.02.010"},{"key":"e_1_2_4_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605849"},{"key":"e_1_2_4_70_1","first-page":"271","article-title":"Combinations of apoptosis and cell\u2010cycle control biomarkers predict the outcome of human melanoma","volume":"20","author":"Piras F","year":"2008","journal-title":"Oncol. Rep."},{"key":"e_1_2_4_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1777"},{"key":"e_1_2_4_72_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.22.8239"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12348","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12348","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:53:20Z","timestamp":1695570800000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12348"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,25]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1111\/ajd.12348"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12348","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"type":"print","value":"0004-8380"},{"type":"electronic","value":"1440-0960"}],"subject":[],"published":{"date-parts":[[2015,5,25]]},"assertion":[{"value":"2015-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-04-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}