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Criteria for inclusion were being an adult with chronic plaque psoriasis, having a psoriasis area and severity index (PASI)<\/jats:styled-content> score of at least 15 with an inadequate response or intolerance to three of the following: phototherapy, acitretin, cyclosporin and methotrexate. Participants were infused with infliximab 5\u2009mg\/kg on the standard induction (weeks 0, 2 and 6) and maintenance (8\u2010weekly) protocols. At each visit PASI<\/jats:styled-content> and dermatology life quality index (DLQI<\/jats:styled-content>) scores were recorded. Success was determined as the proportion of patients achieving at least a 75% improvement in the PASI<\/jats:styled-content> score from baseline (PASI<\/jats:styled-content> 75). At 60 months after commencement of therapy, 31% of patients remained on infliximab. Those who<\/jats:styled-content> did retained PASI<\/jats:styled-content> 75 with a DLQI<\/jats:styled-content> of 0 or 1. Of those who ceased infliximab, nine did so due to loss of efficacy, three for personal reasons, two for serious adverse events and one was lost to follow up. Adverse events included non\u2010melanoma skin cancers, infections and abnormal liver enzymes. Infliximab in the Australian context has proven to be a highly effective treatment of chronic plaque psoriasis, and patients who remained on the drug derived a high level of satisfaction, assessed both subjectively (DLQI<\/jats:styled-content>) and objectively (PASI<\/jats:styled-content> 75). The variable response indicates that psoriasis is a heterogeneous disease and<\/jats:styled-content> investigation into potential patient selection for treatment in the future is warranted.<\/jats:p>","DOI":"10.1111\/ajd.12391","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T08:06:57Z","timestamp":1442390817000},"page":"300-306","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Five\u2010year experience with infliximab: Follow up of the product familiarisation program"],"prefix":"10.1111","volume":"57","author":[{"given":"Rebecca","family":"Nguyen","sequence":"first","affiliation":[{"name":"Skin and Cancer Foundation Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Braue","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital Melbourne Victoria 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