{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T04:13:13Z","timestamp":1695528793229},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T00:00:00Z","timestamp":1442880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The clinical differentiation between pigmented basal cell carcinoma (BCC<\/jats:styled-content>) and other benign pigmented skin lesions can be challenging even with an additional dermoscopic evaluation, especially if the lesion is small. In vivo<\/jats:italic> reflectance confocal microscopy (RCM<\/jats:styled-content>) is an emerging, non\u2010invasive imaging tool that allows near\u2010microscopic evaluation of skin lesions. The features of RCM<\/jats:styled-content> for pigmented BCC<\/jats:styled-content> and seborrhoeic keratosis have previously been described. However, the use of RCM<\/jats:styled-content> to differentiate between these clinically and dermoscopically challenging pigmented skin lesions among A<\/jats:styled-content>sians has not yet been demonstrated.<\/jats:p><\/jats:sec>Objectives<\/jats:title>We aimed to evaluate the usefulness of non\u2010invasive RCM<\/jats:styled-content> to differentiate between clinically and dermoscopically challenging pigmented skin lesions among A<\/jats:styled-content>sians in a series of 11 lesions.<\/jats:p><\/jats:sec>Methods<\/jats:title>Nine patients with 11 clinically and dermoscopically difficult to distinguish pigmented skin lesions were evaluated by RCM<\/jats:styled-content> to differentiate between pigmented BCC<\/jats:styled-content> and benign lesions. In all cases, a histological confirmation of the RCM<\/jats:styled-content> diagnosis was obtained.<\/jats:p><\/jats:sec>Results<\/jats:title>The clinical or dermoscopical characteristics were non\u2010specific in all 10 cases. RCM<\/jats:styled-content> detected features of pigmented BCC<\/jats:styled-content> in nine patients and seborrhoeic keratosis in one patient. These were all confirmed by histological examination.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>This case series shows the value of non\u2010invasive in vivo<\/jats:italic>\u2005RCM<\/jats:styled-content> imaging in the differentiation of malignant and benign pigmented lesions. Early diagnosis of small, pigmented BCC<\/jats:styled-content> allows earlier excision with better prognosis. Future biopsies of benign lesions in cosmetic areas could also be avoided.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12401","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T10:24:59Z","timestamp":1442917499000},"page":"130-134","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Reflectance confocal microscopy is a useful non\u2010invasive tool in the in vivo<\/i> diagnosis of pigmented basal cell carcinoma in A<\/scp>sians"],"prefix":"10.1111","volume":"58","author":[{"given":"Sai Yee","family":"Chuah","sequence":"first","affiliation":[{"name":"Department of Dermatology National Skin Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shang Ian","family":"Tee","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wee Ping","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siong See Joyce","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"See Ket","family":"Ng","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sze Hon","family":"Chua","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tien Guan Steven","family":"Thng","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Skin Centre Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,22]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(96)90007-9"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.063"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajd.12202"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950115)75:2 <667::AID-CNCR2820751409>3.0.CO;2-I"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.05.035"},{"key":"e_1_2_6_7_1","first-page":"62","article-title":"Facial rejuvenation in skin of color","volume":"24","author":"Alexis AF","year":"2011","journal-title":"Cosmet. 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