{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:01:52Z","timestamp":1753887712793,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T00:00:00Z","timestamp":1444089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Proopiomelanocortin (<jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content>) and melanocortin 1 receptor (<jats:styled-content style=\"fixed-case\">MC1R<\/jats:styled-content>) are regulators of melanogenesis and pigmentation. Our objective was to estimate their levels, searching for a possible role of the melanocortin system in vitiligo. This study included 40 vitiligo patients and 40 controls. Skin biopsies were taken from lesional and non\u2010lesional skin of patients and from the non\u2010sun exposed skin of controls to detect the expression of <jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MC1R<\/jats:styled-content> using quantitative real\u2010time polymerase chain reaction. Both factors were significantly lower in lesional than non\u2010lesional skin and controls, while they were significantly higher in non\u2010lesional skin than in controls. There was a statistically significant positive correlation between lesional levels of <jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MC1R<\/jats:styled-content>, as well as between non\u2010lesional levels of <jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">MC1R<\/jats:styled-content> in the patients. On the other hand, we found a statistically significant negative correlation between the lesional and non\u2010lesional levels of <jats:styled-content style=\"fixed-case\">POMC<\/jats:styled-content>, as well as between the lesional and non\u2010lesional levels of <jats:styled-content style=\"fixed-case\">MC1R<\/jats:styled-content> in the patients. As a conclusion, the melanocortin system could play a role in the pathogenesis of vitiligo or could be affected as the end result of the disease.<\/jats:p>","DOI":"10.1111\/ajd.12408","type":"journal-article","created":{"date-parts":[[2015,10,6]],"date-time":"2015-10-06T08:36:45Z","timestamp":1444120605000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Assessment of gene expression levels of proopiomelanocortin (<scp>POMC<\/scp>) and melanocortin\u20101 receptor (<scp>MC1R<\/scp>) in vitiligo"],"prefix":"10.1111","volume":"58","author":[{"given":"Noha A","family":"Nagui","sequence":"first","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara B","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3280-0796","authenticated-orcid":false,"given":"Rania M","family":"Abdel Hay","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"May M","family":"Hassieb","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila A","family":"Rashed","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry Department Faculty of Medicine Cairo University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,6]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700421"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12540"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.3.979"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.06.004"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(00)90133-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.74530"},{"key":"e_1_2_6_9_1","first-page":"243","article-title":"Elevated levels of adrenocorticotropin (ACTH) precursors in post\u2010adrenalectomy Cushing's disease and their regulation by glucocorticoids","volume":"80","author":"Ray DW","year":"1995","journal-title":"J. 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