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Here we report three patients at different stages of disease successfully treated with pentoxifylline, a haemorrheological and anti\u2010inflammatory agent. We demonstrate for the first time that early stage <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content> may be completely reversible with this treatment. Our findings are also consistent with previous isolated reports showing the effectiveness of pentoxifylline in treating ulcerative <jats:styled-content style=\"fixed-case\">NL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ajd.12420","type":"journal-article","created":{"date-parts":[[2015,11,12]],"date-time":"2015-11-12T07:02:58Z","timestamp":1447311778000},"page":"65-68","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Pentoxifylline: An effective therapy for necrobiosis lipoidica"],"prefix":"10.1111","volume":"58","author":[{"given":"Edmund","family":"Wee","sequence":"first","affiliation":[{"name":"Department of Dermatology St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Kelly","sequence":"additional","affiliation":[{"name":"Department of Dermatology St Vincent's Hospital Melbourne  Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,11,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.05.034"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.98023"},{"key":"e_1_2_7_4_1","first-page":"581","article-title":"[Cutaneous microcirculation in pretibial necrobiosis lipoidica. 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