{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T07:11:02Z","timestamp":1770534662234,"version":"3.49.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,1,14]],"date-time":"2016-01-14T00:00:00Z","timestamp":1452729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001779","name":"Monash University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001779","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Scalp melanoma has a worse prognosis than melanoma elsewhere, though the reasons for this are poorly understood. Current literature describing the clinicopathological associations of scalp melanoma is sparse. This study aims to compare clinical and histological features of scalp melanoma with other cutaneous head and neck melanomas (<jats:styled-content style=\"fixed-case\">CHNM<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study was performed of all primary<jats:styled-content style=\"fixed-case\">CHNM<\/jats:styled-content>cases seen by the Victorian Melanoma Service between 1994 and 2014, using prospectively recorded clinical data. Invasive and<jats:italic>in\u00a0situ<\/jats:italic>melanomas were compared separately.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Invasive scalp melanoma was associated with male sex (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.7; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.9\u20133.9), increasing age (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.02 per year increase in age; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.01\u20131.03), being first noticed by a person other than self, spouse\/relative or doctor (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 2.9; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.5\u20135.7), amelanosis (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.6; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.1\u20132.3), and increased growth rate (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.14 per 1\u00a0mm\/month growth rate increase; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.04\u20131.26). Compared with other<jats:styled-content style=\"fixed-case\">CHNM<\/jats:styled-content>, scalp melanoma had greater median Breslow thickness (2.8\u00a0<jats:italic>vs<\/jats:italic>1.2\u00a0mm) and was independently associated with satellite metastases (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 4.7; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.9\u201311.5) and nodular subtype (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>, 1.8; 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.1\u20133.1).<jats:italic>In situ<\/jats:italic>scalp melanoma was associated with male sex, increasing age and solar keratoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Scalp melanoma tends to occur in older men, is often rapidly growing and amelanotic, and is associated with high risk histological features. As it is likely to be overlooked, increased recognition of the atypical presentations of scalp melanoma is required.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12437","type":"journal-article","created":{"date-parts":[[2016,1,15]],"date-time":"2016-01-15T12:48:30Z","timestamp":1452862110000},"page":"181-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Scalp melanoma: Distinctive high risk clinical and histological features"],"prefix":"10.1111","volume":"58","author":[{"given":"Charles","family":"Xie","sequence":"first","affiliation":[{"name":"Victorian Melanoma Service The Alfred Hospital Melbourne Victoria Australia"},{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Pan","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catriona","family":"McLean","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Mar","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rory","family":"Wolfe","sequence":"additional","affiliation":[{"name":"School of Public Health and Preventive Medicine Monash University Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John W","family":"Kelly","sequence":"additional","affiliation":[{"name":"Victorian Melanoma Service The Alfred Hospital Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,14]]},"reference":[{"issue":"1","key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1288\/00005537-198908000-00010","article-title":"Cutaneous malignant melanoma of the head and neck","volume":"99","author":"Fisher SR","year":"1989","journal-title":"Laryngoscope"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07455.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0b013e3283577b96"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19950515)75:10<2492::AID-CNCR2820751015>3.0.CO;2-W"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812444268"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.12.1551"},{"key":"e_1_2_7_8_1","volume-title":"World Health Organization. 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