{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T23:52:58Z","timestamp":1790553178567,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,11]],"date-time":"2016-03-11T00:00:00Z","timestamp":1457654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Demodex mite density is emphasised in the aetiopathogenesis of acne rosacea. Reflectance confocal microscopy (<jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content>) has been shown to be a good method for determining demodex mite density. The objective was to determine demodex mite density using <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> in acne rosacea patients and compare them with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In all, 30 papulopustular rosacea (<jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content>) and 30 erythematotelangiectatic rosacea (<jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content>) totally 60 acne rosacea patients and 40 controls, were enrolled in the study. The right cheek was selected for imaging and <jats:styled-content style=\"fixed-case\">RCM<\/jats:styled-content> was used for scanning. Ten images of 1000 \u00d7 1000 \u03bcm (total 10 mm<jats:sup>2<\/jats:sup>) area were scanned from adjacent areas. The numbers of follicles, infested follicles and mites were counted. The mean numbers of mites per follicle and infested follicles were calculated and compared in the patients and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean number of mites was 44.30 \u00b1 23.22 in <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content>, 14.57 \u00b1 15.86 in <jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content> and 3.55 \u00b1 6.48 in the control group (<jats:italic>P<\/jats:italic> &lt; 0.001). The mean number of mites per follicle was 1.77 \u00b1 0.90 in <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content>, 0.57 \u00b1 0.63 in <jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content> and 0.13 \u00b1 0.23 in the control group (<jats:italic>P<\/jats:italic> &lt; 0.001). The cut\u2010off for the mean number of mites for determining mite infestation was 0.17 and above.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Demodex mite density was markedly increased in both <jats:styled-content style=\"fixed-case\">ETR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PPR<\/jats:styled-content> patients. It is believed that the presence of demodex mites plays an important role in rosacea aetiopathogenesis. Demodex mite treatment may reduce the severity of the disease and slow its progressive nature.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12452","type":"journal-article","created":{"date-parts":[[2016,3,12]],"date-time":"2016-03-12T20:59:02Z","timestamp":1457816342000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Demodex mites in acne rosacea: reflectance confocal microscopic study"],"prefix":"10.1111","volume":"58","author":[{"given":"Asli","family":"Turgut Erdemir","sequence":"first","affiliation":[{"name":"Department of Dermatology Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Salih","family":"Gurel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Esra","family":"Koku Aksu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tugba","family":"Falay","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esma","family":"Inan Yuksel","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebru","family":"Sarikaya","sequence":"additional","affiliation":[{"name":"Department of Dermatology Istanbul Training and Research Hospital Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,11]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082564"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1993.tb00261.x"},{"key":"e_1_2_6_4_1","first-page":"801","article-title":"Rosacea: histopathologic study of 75 cases","volume":"115","author":"Ramelet AA","year":"1988","journal-title":"Ann. Dermatol. Venereol."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.144.12.1597"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13148"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12259"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03134.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2012.00615.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.141.10.1336"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2011.1518"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10645.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.193"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11096.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-7310(08)74672-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(93)70065-2"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.03.030"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100285"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B1100179"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/09286586.2011.642052"},{"key":"e_1_2_6_21_1","first-page":"640","article-title":"Association of demodicosis with acne rosacea","volume":"26","author":"Tas Cengiz Z","year":"2010","journal-title":"Pak. J. Med. Sci."},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08028.x"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09645.x"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12137"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1998.00218.x"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12452","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12452","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:44:11Z","timestamp":1695509051000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,11]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/ajd.12452"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12452","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,11]]},"assertion":[{"value":"2015-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2015-12-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}