{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:02:56Z","timestamp":1790254976082,"version":"4.1.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Mucosal\u2010associated invariant T (<jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content>) cells are a novel subset of innate\u2010like T\u2010cells that are enriched in mucosal tissues. Their presence in human skin has only recently been recognised. We describe the expression of skin\u2010tropic molecules on human skin <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells at steady state and investigate their contribution to various dermatoses with known T\u2010cell involvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To examine the expression of skin\u2010tropic molecules by <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells at steady state, we performed a flow cytometric analysis of blood and skin samples from healthy donors. To investigate any potential wider contribution of <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells to skin disease, we examined psoriasis, alopecia areata and dermatitis herpetiformis biopsies using immunofluorescent staining to identify the proportion of T\u2010cells expressing <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cell surface markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found that <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells constituted a small population of T\u2010cells in normal human skin, similar to the percentage found in peripheral blood. Like other skin T\u2010cells, skin <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells expressed high levels of the skin\u2010associated markers, cutaneous lymphocyte antigen and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>103. In psoriasis and alopecia areata the proportion of <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells was similar to that found in normal skin, but in dermatitis herpetiformis it was significantly elevated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The expression of skin\u2010tropic molecules by skin <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells is consistent with their resident status in normal human skin. Our results suggest that <jats:styled-content style=\"fixed-case\">MAIT<\/jats:styled-content> cells may play a role in the pathogenesis of dermatitis herpetiformis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12456","type":"journal-article","created":{"date-parts":[[2016,3,5]],"date-time":"2016-03-05T16:30:05Z","timestamp":1457195405000},"page":"200-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["The frequency of mucosal\u2010associated invariant T cells is selectively increased in dermatitis herpetiformis"],"prefix":"10.1111","volume":"58","author":[{"given":"Jane","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology Peter Doherty Institute for Infection and Immunity University of Melbourne Melbourne Victoria Australia"},{"name":"Department of Medicine St Vincent's Hospital University of Melbourne Melbourne Victoria 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