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Associated liver disease limits therapeutic options and necessitates careful monitoring. The aim of the study was to identify liver problems in psoriasis patients and to investigate the underlying causes as well as their course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The files of 518 psoriasis patients were retrospectively reviewed. Among these, 393 patients with relevant laboratory data were analysed for liver enzymes and their relation to the known risk factors for liver disease (obesity, diabetes mellitus, alcohol consumption, hepatotoxic medications, dyslipidemia, psoriatic arthritis and infectious hepatitis).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 393 patients, 24% and 0.8% developed liver enzyme abnormalities and cirrhosis, respectively. The most common factors associated with pathological liver enzymes were drugs (57%) and <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> (22%). Other rare causes were alcoholic hepatitis, viral hepatitis, neutrophilic cholangitis, autoimmune hepatitis and toxic hepatitis due to herbal therapy. Drug\u2010induced liver enzyme abnormalities were reversible whereas in patients with <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content> transaminases tended to fluctuate. One patient with herbal medicine\u2010related cirrhosis died of sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Liver enzyme abnormalities are common in psoriasis patients and are mostly associated with drugs and <jats:styled-content style=\"fixed-case\">NAFLD<\/jats:styled-content>. Although most cases can be managed by avoiding hepatotoxic medications and close follow up, severe consequences like cirrhosis may develop.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12460","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T07:52:49Z","timestamp":1456473169000},"page":"194-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Psoriasis and the liver: problems, causes and course"],"prefix":"10.1111","volume":"58","author":[{"given":"Elona","family":"Tula","sequence":"first","affiliation":[{"name":"Department of Dermatology Corlu Vatan Hospital Tekirdag Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tulin","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Dermatology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilek","family":"Seckin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleyha","family":"Ozgen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erol","family":"Avsar","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Marmara University School of Medicine Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,2,24]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.02.039"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8019.2010.01312.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(99)70112-X"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.143.12.1493"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.06.008"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.020"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.11.906"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03841.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.05002.x"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2003.02958.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510300604"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06440.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.122"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2008.08780.x"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.103"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.2165\/00044011-200626020-00001"},{"key":"e_1_2_5_19_1","first-page":"1454","article-title":"Drug use and toxicity in psoriatic disease: focus on methotrexate","volume":"35","author":"Taylor WJ","year":"2008","journal-title":"J. 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