{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T18:14:40Z","timestamp":1782929680856,"version":"3.54.5"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,3,21]],"date-time":"2016-03-21T00:00:00Z","timestamp":1458518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000982","name":"Rural Industries Research and Development Corporation","doi-asserted-by":"publisher","award":["PRJ\u2010006245"],"award-info":[{"award-number":["PRJ\u2010006245"]}],"id":[{"id":"10.13039\/501100000982","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The efficacy, tolerability and acceptability of a tea tree oil gel (200 mg\/g) and face wash (7 mg\/g) were evaluated for the treatment of mild to moderate facial acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this open\u2010label, uncontrolled phase <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> pilot study, participants applied tea tree oil products to the face twice daily for 12 weeks and were assessed after 4, 8 and 12 weeks. Efficacy was determined from total numbers of facial acne lesions and the investigator global assessment (<jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content>) score. Tolerability was evaluated by the frequency of adverse events and the mean tolerability score determined at each visit. Product acceptability was assessed via a questionnaire at the end of the study period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 18 participants were enrolled, of whom 14 completed the study. Mean total lesion counts were 23.7 at baseline, 17.2 at 4, 15.1 at 8 and 10.7 at 12 weeks. Total lesion counts differed significantly over time by repeated measures <jats:sc>anova<\/jats:sc> (<jats:italic>P<\/jats:italic> &lt; 0.0001). The mean <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> score was 2.4 at baseline, 2.2 at 4, 2.0 at 8 and 1.9 at 12 weeks, which also differed significantly over time (<jats:italic>P<\/jats:italic> = 0.0094). No serious adverse events occurred and minor local tolerability events were limited to peeling, dryness and scaling, all of which resolved without intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study shows that the use of the tea tree oil products significantly improved mild to moderate acne and that the products were well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12465","type":"journal-article","created":{"date-parts":[[2016,3,22]],"date-time":"2016-03-22T10:26:51Z","timestamp":1458642411000},"page":"205-210","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Tea tree oil gel for mild to moderate acne; a 12 week uncontrolled, open\u2010label phase <scp>II<\/scp> pilot study"],"prefix":"10.1111","volume":"58","author":[{"given":"Harsimran Kaur","family":"Malhi","sequence":"first","affiliation":[{"name":"Department of General Medicine St John of God Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Perth Hospital Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V","family":"Riley","sequence":"additional","affiliation":[{"name":"PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre Perth Western Australia Australia"},{"name":"School of Pathology and Laboratory Medicine (M504) University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujith Prasad","family":"Kumarasinghe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Perth Hospital Perth Western Australia Australia"},{"name":"Hollywood Medical Centre Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Hammer","sequence":"additional","affiliation":[{"name":"School of Pathology and Laboratory Medicine (M504) University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00890.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.1997.tb01126.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354887"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.375"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.2165\/11634040-000000000-00000"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.50-62.2006"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.10.011"},{"key":"e_1_2_8_9_1","unstructured":"Clinical and Laboratory Standards Institute.Methods for antimicrobial susceptibility testing of anaerobic bacteria; approved standard eighth edition. 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