{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:43:29Z","timestamp":1787013809823,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T00:00:00Z","timestamp":1457395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Penile intraepithelial neoplasia (\n                    <jats:styled-content style=\"fixed-case\">PIN<\/jats:styled-content>\n                    ), or penile squamous cell carcinoma\n                    <jats:italic>in situ<\/jats:italic>\n                    , is a rare disease and may be associated with high morbidity and mortality. In an attempt to avoid surgical intervention, which may result in poor cosmetic and functional outcomes for patients, many non\u2010invasive treatments have been trialled with variable success rates. This review summarises the available literature describing the use of topical imiquimod for\n                    <jats:styled-content style=\"fixed-case\">PIN<\/jats:styled-content>\n                    . While the results of our review are limited by the heterogeneity of the methods and follow ups of the included case series and case reports, they highlight the fact that patients with\n                    <jats:styled-content style=\"fixed-case\">PIN<\/jats:styled-content>\n                    have variable responses to imiquimod which seem less effective than previously reported. Therefore, if imiquimod treatment is instituted in\n                    <jats:styled-content style=\"fixed-case\">PIN<\/jats:styled-content>\n                    , clinicians should counsel their patients about the effects associated with treatment, the potential for a partial or no response to treatment, and the risk of recurrence. A strict follow\u2010up plan is also necessary to monitor both patient adherence and\n                    <jats:styled-content style=\"fixed-case\">PIN<\/jats:styled-content>\n                    recurrence after treatment completion, in case surgical options need to be considered.\n                  <\/jats:p>","DOI":"10.1111\/ajd.12466","type":"journal-article","created":{"date-parts":[[2016,3,8]],"date-time":"2016-03-08T04:14:37Z","timestamp":1457410477000},"page":"86-92","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Imiquimod in the treatment of penile intraepithelial neoplasia: An update"],"prefix":"10.1111","volume":"58","author":[{"given":"Kristyn","family":"Deen","sequence":"first","affiliation":[{"name":"Department of Dermatology Mater Misericordiae Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Burdon\u2010Jones","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mater Misericordiae Hospital Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,3,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-008-0302-z"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-008-9276-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/1756287211412657"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S1109"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001432-200304000-00004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986707780059625"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08265.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.119103"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120584"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063140"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.126580"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120444"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.05019.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.28.s1.2.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.28.s1.3.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0366-077X.2003.05635.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-9740.2004.03451.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1258\/0956462042563774"},{"key":"e_1_2_7_20_1","first-page":"278","article-title":"Bowenoid papulosis in a patient with AIDS treated with imiquimod: Case report","volume":"12","author":"Nunes MG","year":"2004","journal-title":"Acta Dermatovenerol. Croat."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1610-0387.2006.06005.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.07.021"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2006.06368.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700578"},{"key":"e_1_2_7_25_1","first-page":"483","article-title":"Case reports: Bowen's disease of the penis treated with topical imiquimod 5% cream","volume":"7","author":"Talifaferro SJ","year":"2008","journal-title":"J. Drugs Dermatol."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.03083.x"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630802562435"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322009001000005"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2009.21.4.419"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330328"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02014.x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2012.02.052"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462412474730"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2013-051184.0348"},{"key":"e_1_2_7_35_1","first-page":"22337","article-title":"Pigmented Bowen's disease of the penis and scrotum in a patient with AIDS","volume":"20","author":"Al\u2010Dawsari NA","year":"2014","journal-title":"Dermatol. Online J."},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1159\/000354652"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12103"},{"key":"e_1_2_7_38_1","first-page":"797","article-title":"Treatment of Bowen's disease of the penis with imiquimod 5% cream","volume":"29","author":"Diego RE","year":"2005","journal-title":"Actas Urol. Esp."},{"key":"e_1_2_7_39_1","first-page":"472","article-title":"Intraepithelial neoplasia grade 3 of the penis glans","volume":"20","author":"Uffen MP","year":"2010","journal-title":"Ned. Tijdschr. Geneeskd."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12029"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2008.34172.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)65650-9"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000067361.81295.a2"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365590701428590"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0130"},{"key":"e_1_2_7_46_1","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1001\/jama.1975.03250090024012","article-title":"Erythroplasia of Queyrat. Treatment with topically applied fluorouracil","volume":"232","author":"Goette DK","year":"1975","journal-title":"JAMA"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2010.481284"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1258\/ijsa.2009.009309"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2007.01.002"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/archdermatol.2011.218"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2012.04361.x"},{"key":"e_1_2_7_52_1","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1684\/ejd.2015.2568","article-title":"Two cases of erythroplasia of Queyrat with persistent post\u2010treatment inflammation after histological remission of epithelial dysplasia","volume":"25","author":"Fismen S","year":"2015","journal-title":"Eur. J. Dermatol."}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T18:44:45Z","timestamp":1695494685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3,8]]},"references-count":51,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/ajd.12466"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12466","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,3,8]]},"assertion":[{"value":"2015-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}