{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T16:23:56Z","timestamp":1764174236639},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,30]],"date-time":"2016-03-30T00:00:00Z","timestamp":1459296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Although many treatments are available to address hyperhidrosis, the results are not always satisfactory. The aim of the study was to assess the effectiveness, optimal dosage regimen and long\u2010term safety of oral oxybutynin in the treatment of hyperhidrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review was performed on 110 patients who underwent treatment for hyperhidrosis between February 2007 and December 2013. Their response to treatment was evaluated using the hyperhidrosis disease severity scale at baseline, 3 and 12 months. Additionally, the safety and effectiveness of different up\u2010dosing and fixed\u2010dose regimens were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 3 months of treatment, 87 of the 110 patients (79%) had responded (63%), which was considered excellent. After 12 months, 63 patients (62%) continued to respond, and the response was considered excellent in 50%. Nine patients were lost to follow up between month 3 and 12. In total, 77 and 70% of the patients who responded at 3 and 12 months, respectively, reported mild adverse events. No serious adverse events were observed. Treatment adherence was significantly higher among patients following the individualised up\u2010dosing regimen.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Oral oxybutynin may be an effective and safe option for the long\u2010term treatment of hyperhidrosis. To improve treatment adherence, oxybutynin dosing regimens should be individualised on the basis of the patient's tolerance and response.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12473","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T04:42:49Z","timestamp":1459399369000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Oral oxybutynin for the treatment of hyperhidrosis: outcomes after one\u2010year follow\u2010up"],"prefix":"10.1111","volume":"58","author":[{"given":"Jos\u00e9 Francisco","family":"Mill\u00e1n\u2010Cayetano","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"},{"name":"University of M\u00e1laga M\u00e1laga Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"del Boz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Rivas\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Research Unit Hospital Costa del Sol Marbella Spain"},{"name":"Red de Investigaci\u00f3n en Servicios de Salud en Enfermedades Cr\u00f3nicas Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Bl\u00e1zquez\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Hern\u00e1ndez Ib\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"de Troya\u2010Mart\u00edn","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Costa del Sol Marbella Spain"},{"name":"Red de Investigaci\u00f3n en Servicios de Salud en Enfermedades Cr\u00f3nicas Marbella Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,30]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.142.8.1065"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0392"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630701418754"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0828"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.avsg.2011.06.007"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12385"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-014-0264-8"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.12729"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.05.087"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(09)06"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33192.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2011.12.039"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2014(02)05"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2011.07.002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2012.05746.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12142"},{"key":"e_1_2_6_18_1","first-page":"520","article-title":"[Use of oral oxybutynin at 7.5 mg per day in primary hyperhidrosis]","volume":"67","author":"Try C","year":"2012","journal-title":"Rev. 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