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However, some patients (nonresponders) do not respond to this treatment because they do not have an allergic reaction to DCP<\/jats:styled-content>. The aim of this study was to investigate the potential role of imiquimod in inducing an allergic reaction to DCP<\/jats:styled-content> in nonresponders. In all, 20 nonresponders were recruited from a group of DCP<\/jats:styled-content>\u2010treated AA<\/jats:styled-content> patients. Of these patients, 10 were treated with DCP<\/jats:styled-content> and topical imiquimod and 10 were treated with DCP<\/jats:styled-content> alone. A significantly better therapeutic outcome was measured in the DCP<\/jats:styled-content> plus imiquimod group than in the group treated with DCP<\/jats:styled-content> alone. The potential mechanism of imiquimod may involve the role of interleukin\u201012, as previously suggested in an animal model. These findings suggest that imiquimod may have the potential to improve prognosis in nonresponder AA<\/jats:styled-content> patients treated with DCP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/ajd.12478","type":"journal-article","created":{"date-parts":[[2016,4,18]],"date-time":"2016-04-18T02:43:09Z","timestamp":1460947389000},"page":"219-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Possible advantage of imiquimod and diphenylcyclopropenone combined treatment versus diphenylcyclopropenone alone: An observational study of nonresponder patients with alopecia areata"],"prefix":"10.1111","volume":"58","author":[{"given":"Tomasz","family":"Wasy\u0142yszyn","sequence":"first","affiliation":[{"name":"Department of Dermatology Medical Center Gabinet Dermatologiczny Tomasz Wasy\u0142yszyn Warsaw Poland"},{"name":"Department of Pathomorphology Military Institute of Medicine in Warsaw Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Borowska","sequence":"additional","affiliation":[{"name":"Department of Dermatology Medical Center CADERM Warsaw Poland"},{"name":"Department of Histology and Embryology with Experimental Cytology Unit Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,4,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.04.036"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-007-0759-4"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09827.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)90851-6"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0192-0561(98)00068-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.05.091"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm049211v"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03327.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700167"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.1983"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199404000-00011"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12478","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12478","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12478","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:35:07Z","timestamp":1695569707000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12478"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,17]]},"references-count":11,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,8]]}},"alternative-id":["10.1111\/ajd.12478"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12478","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,17]]},"assertion":[{"value":"2015-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-02-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}