{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T23:48:31Z","timestamp":1725061711865},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T00:00:00Z","timestamp":1463011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Pneumocystis jirovecii<\/jats:italic> pneumonia (<jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content>) is a relatively rare complication in non\u2010<jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content> patients receiving immunosuppressive treatment. Since the introduction of tumour necrosis factor\u2010\u03b1 inhibitors cases of this complication have increased. We report the case of a 54\u2010year\u2010old, HIV\u2010negative patient, who presented to our department with a long history of pustular psoriasis with poor response to traditional treatments. During the last admission he developed a severe flare that was unresponsive to cyclosporine, therefore infliximab was initiated. After the third dose he developed <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content> that required admission to the intensive care unit, with a positive response to i.v. administration of trimethoprim\/sulfamethoxazole. During follow up a mutation in the <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>36<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content><\/jats:italic> gene compatible with an <jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content><\/jats:italic> deficiency was found and anakinra was started, with rapid improvement of his psoriasis. <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content> is a severe complication in patients receiving immunosuppressive therapy and is probably underreported by dermatologists. There are no clinical guidelines for <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content> prophylaxis in dermatological patients who will receive immunosuppressive or biological treatments. We believe that it is necessary to report the cases of <jats:styled-content style=\"fixed-case\">PCP<\/jats:styled-content> to assess the real impact of this complication and develop appropriate prophylaxis guidelines.<\/jats:p>","DOI":"10.1111\/ajd.12489","type":"journal-article","created":{"date-parts":[[2016,5,12]],"date-time":"2016-05-12T07:55:43Z","timestamp":1463039743000},"update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>Pneumocystis jirovecii<\/i> pneumonia in a patient with pustular psoriasis with an <scp>IL<\/scp>\u201036<scp>RN<\/scp> deficiency treated with infliximab: Case report and review of the literature"],"prefix":"10.1111","volume":"58","author":[{"given":"Sebastian","family":"Podlipnik","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Clinic, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorena","family":"de la Mora","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Hospital Clinic, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Merc\u00e8","family":"Alsina","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Clinic, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Jos\u00e9 M","family":"Mascar\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Clinic, University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,12]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq242"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9250-x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.07.042"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.11.588"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04857.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2000.03756.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.494412.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc070728"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06066-11"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit071"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb08274.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70088-X"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1999.03052.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2003.20615.x"}],"container-title":["Australasian Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fajd.12489","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/ajd.12489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T22:44:16Z","timestamp":1695509056000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/ajd.12489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,12]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/ajd.12489"],"URL":"https:\/\/doi.org\/10.1111\/ajd.12489","archive":["Portico"],"relation":{},"ISSN":["0004-8380","1440-0960"],"issn-type":[{"value":"0004-8380","type":"print"},{"value":"1440-0960","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,12]]},"assertion":[{"value":"2015-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-03-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}