{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T18:37:21Z","timestamp":1760985441249,"version":"3.30.2"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T00:00:00Z","timestamp":1465516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Squamous cell carcinoma of the scalp is a common clinical problem in an aging population. Despite its high incidence, little has been documented regarding treatment or outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analysed 235 cases treated with curative intent at Peter MaCallum Cancer Centre between 1998 and 2010. The cohort was analysed for its characteristics, management, survival and prognostic factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients were primarily male (88%) with a median age of 79 years (range 53\u201398 years). There was a high proportion of immunosuppressed patients (29%) and stage T2 (48%) tumours. Management included surgery (45%), radiotherapy (28%) and surgery and adjuvant radiotherapy (26%). Median follow up from treatment was 4.5 years. Estimated 5\u2010year overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>), disease\u2010specific survival and progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) were 59, 94 and 51%, respectively. The 5\u2010year cumulative incidence of local and regional relapse was 11 and 7%, respectively. There were four patients who developed distant metastases and died of their disease. Statistically significant prognostic factors identified for poor outcomes for <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> were T2 stage (hazard ratio [1.7 and 2.1) and immunosuppression (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> 3.3 and 3.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude the presence of immunosuppression and T2 stage is prognostic for survival. Further research to establish treatment principles is warranted.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12520","type":"journal-article","created":{"date-parts":[[2016,6,10]],"date-time":"2016-06-10T10:58:44Z","timestamp":1465556324000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Outcomes following management of squamous cell carcinoma of the scalp: A retrospective series of 235 patients treated at the Peter MacCallum Cancer Centre"],"prefix":"10.1111","volume":"58","author":[{"given":"Vanessa","family":"Estall","sequence":"first","affiliation":[{"name":"Liverpool Hospital Cancer Therapy Centre Sydney New South Wales Australia"},{"name":"University of Melbourne Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Allen","sequence":"additional","affiliation":[{"name":"Waikato Regional Cancer Centre Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Webb","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Bressel","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"McCormack","sequence":"additional","affiliation":[{"name":"Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Spillane","sequence":"additional","affiliation":[{"name":"University of Melbourne Melbourne Victoria Australia"},{"name":"Peter MacCallum Cancer Centre Melbourne Victoria Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,6,10]]},"reference":[{"unstructured":"Australian Institute of Health and Welfare & Cancer Australia.Non\u2010melanoma skin cancer. 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