{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:32:07Z","timestamp":1777901527821,"version":"3.51.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T00:00:00Z","timestamp":1468972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012747","name":"Douglas Pharmaceuticals, Auckland, New Zealand","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100012747","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Rosacea is a chronic inflammatory disorder that affects up to 10% of the population. Standard treatments include topical azelaic acid and metronidazole or systemic tetracyclines. Isotretinoin has generally been restricted to severe disease, often at a dose of 0.5\u20131.0\u00a0mg\/kg\/day.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Retrospective review of open\u2010label isotretinoin (initial dose 20\u00a0mg\/day, with dose adjustments according to response), in patients with mild to moderate papulopustular rosacea.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 52 patients (33 women), mean age 48\u00a0years (range 18\u201386) were treated with isotretinoin over a 5\u2010year period. All patients were commenced on 20\u2010mg isotretinoin\/day which was reduced to 10\u201320\u00a0mg once to five times a week (equivalent to 5\u00a0mg\/day) in 67%, but increased in 15% (who all had additional acne) to 30\u201340\u00a0mg\/day. In terms of dose\/kg\/day, 29% received \u2264\u00a00.1\u00a0mg\/kg\/day, 46% received 0.11\u20130.25\u00a0mg\/kg\/day and 10% received &gt;\u00a00.5\u00a0mg\/kg\/day. Treatment was continued for 57\u00a0weeks (range 9\u2013223). Six patients (12%) did not attend follow up. Of the remainder, in 91% (42\/46) the rosacea had cleared or was excellent. One patient stopped isotretinoin because of its adverse effects. Two\u2010fifths (44%) suffered no adverse effect. The most common side\u2010effect was cheilitis in half (52%), which was mild in all but one patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Very low\u2010dose isotretinoin (e.g., 10\u201320\u00a0mg once to five times a week, equivalent to 5\u00a0mg\/day) is an effective treatment for mild to moderate papulopustular rosacea and is well tolerated.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12522","type":"journal-article","created":{"date-parts":[[2016,7,20]],"date-time":"2016-07-20T09:07:08Z","timestamp":1469005628000},"page":"26-30","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Very low\u2010dose isotretinoin in mild to moderate papulopustular rosacea; a retrospective review of 52 patients"],"prefix":"10.1111","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-6748","authenticated-orcid":false,"given":"Marius","family":"Rademaker","sequence":"first","affiliation":[{"name":"Waikato Clinical Campus Auckland School of Medicine Auckland New Zealand"},{"name":"Department of Dermatology Waikato Hospital Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,7,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.045"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09894.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.06.009"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.2014.945423"},{"key":"e_1_2_7_7_1","first-page":"18","article-title":"Consensus recommendations from the American Acne & Rosacea Society on the management of rosacea, Part 3: a status report on systemic therapies","volume":"93","author":"Del Rosso JQ","year":"2014","journal-title":"Cutis"},{"key":"e_1_2_7_8_1","first-page":"CD003262","article-title":"Interventions for rosacea","volume":"4","author":"Van Zuuren EJ","year":"2015","journal-title":"Cochrane Database Syst. 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