{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T10:04:24Z","timestamp":1781690664218,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T00:00:00Z","timestamp":1488153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis has been associated with metabolic syndrome and with an increased cardiovascular risk especially in patients with severe disease. The goal of this study was to estimate the prevalence of metabolic syndrome and other cardiovascular risk factors and its association with the psoriasis severity, sex and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with psoriasis were enrolled in a prospective study over a 1\u2010year period. Blood samples were collected. Psoriasis area and severity index (PASI) and body surface area scores and two dermatology quality of life (DQOL) questionnaires were used to evaluate psoriasis severity and the impact of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Altogether 178 patients were included, of whom 44% had moderate\u2013severe psoriasis. The overall prevalence of metabolic syndrome was 30% (men 34%, women 26%) without significant differences between patients with severe and mild disease. Age and menopause appeared to increase the risk for metabolic syndrome. Patients with severe psoriasis smoked more heavily, were more likely to have diabetes or insulin resistance and had higher homocysteine and lower high density lipoprotein cholesterol (<jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C) levels than patients with mild psoriasis (<jats:italic>P &lt;<\/jats:italic> 0.05). In women, a higher waist circumference was observed. Women had higher <jats:styled-content style=\"fixed-case\">HDL<\/jats:styled-content>\u2010C levels and lower smoking and alcohol consumption rates. In accordance with the systematic coronary risk evaluation system, 18% of the patients had a high 10\u2010year risk of fatal cardiovascular disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Psoriasis severity was associated with diabetes, insulin\u2010resistance, smoking habit and higher cardiovascular risk. Metabolic syndrome was related to age and menopause but not to psoriasis severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12577","type":"journal-article","created":{"date-parts":[[2017,2,27]],"date-time":"2017-02-27T10:52:46Z","timestamp":1488192766000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Factors influencing cardiometabolic risk profile in patients with psoriasis"],"prefix":"10.1111","volume":"59","author":[{"given":"Neus","family":"Curc\u00f3","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Barriendos","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9","family":"Barahona","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Arteaga","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Yordanov","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olimpia","family":"De La Barrera","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Prat","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pere","family":"Vives","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari M\u00fatua Terrassa Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Gim\u00e9nez","sequence":"additional","affiliation":[{"name":"Research Unit M\u00fatua Terrassa Research Foundation University of Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"504","article-title":"Prevalence of psoriasis in Spain in the age of biologics","volume":"105","author":"Ferr\u00e1ndiz C","year":"2014","journal-title":"Actas Dermosifiliogr."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04410.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10494.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03656.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01261.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-013-0052-6"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-s064"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.285.19.2486"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000107251.49515.c2"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-8932(07)75064-9"},{"key":"e_1_2_7_12_1","first-page":"12","article-title":"Prevalencia del sindrome metab\u00f3lico en pacientes con psoriasis grave","volume":"94","author":"Arias S","year":"2009","journal-title":"Actual. 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