{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:44:12Z","timestamp":1758980652020,"version":"3.37.3"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,23]],"date-time":"2018-05-23T00:00:00Z","timestamp":1527033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>Patients on biologic therapy are thought to be at increased risk of developing non\u2010melanoma skin cancers and melanomas. It is unknown whether biologic therapy alters the natural history of melanocytic naevi. Therefore, a prospective observational study was conducted to determine whether psoriasis patients on biologic therapy develop changes in naevi.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Clinical and dermoscopic assessment of all melanocytic naevi was performed in 45 psoriasis patients on biologic therapy versus a control cohort of 43 subjects, using sequential digital dermoscopic imaging and total body photography. The mean follow\u2010up period was 1.5\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study and control patients had comparable age, gender, previous and family history of non\u2010melanoma skin cancers and melanomas, as well as previous sun exposure and total number of naevi. The number of naevi with major dermoscopic changes was 3% in the study and 1.9% in the control group, with an adjusted incidence rate ratio of 1.45 (95% confidence interval 0.90\u20132.33; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.125). The rate of minor changes was 15.9% in the study group versus 19.4% in the control (adjusted incidence rate ratio 0.77, 95% confidence interval 0.57\u20131.08; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.14). There were six new dysplastic naevi in 4\/45 biologic patients and four in 4\/43 controls; however, the difference was not significant (relative risk 0.96, 95% confidence interval \u22120.12 to 0.12; <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.95). There were no melanomas in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over a mean follow\u2010up period of 1.5\u00a0years there was no evidence of significantly different changes in naevi or development of new dysplastic naevi in psoriasis patients on biologic treatment compared to controls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12838","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T02:00:22Z","timestamp":1527127222000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A prospective observational study of pigmented naevi changes in psoriasis patients on biologic therapy"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6010-7964","authenticated-orcid":false,"given":"Seohee Deanne","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Dermatology Royal Prince Alfred Hospital Camperdown NSW Australia"},{"name":"Discipline of Dermatology Sydney Medical School University of Sydney Sydney NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario I","family":"D'Souza","sequence":"additional","affiliation":[{"name":"Sydney Local Health District Clinical Research Centre Royal Prince Alfred Hospital Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott W","family":"Menzies","sequence":"additional","affiliation":[{"name":"Discipline of Dermatology Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Sydney Melanoma Diagnostic Centre Royal Prince Alfred Hospital Camperdown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Weninger","sequence":"additional","affiliation":[{"name":"Department of Dermatology Royal Prince Alfred Hospital Camperdown NSW Australia"},{"name":"Discipline of Dermatology Sydney Medical School University of Sydney Sydney NSW Australia"},{"name":"Immune Imaging Program Centenary Institute Newtown NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.339"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10149.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2009.03.003"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.04.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.031"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2004.02186.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10271.x"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199506000-00002"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.137.12.1583"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90078-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.107504"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700269"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1997.03890440049008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2015.1027167"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201244"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546631003681086"},{"key":"e_1_2_8_18_1","first-page":"126","article-title":"Melanocytic nevus count and dermoscopic features do not differ in psoriatic patients undergoing biological agent versus conventional drug therapy","volume":"152","author":"Pirmit S","year":"2017","journal-title":"G. 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