{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T20:56:52Z","timestamp":1763499412651,"version":"3.37.3"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T00:00:00Z","timestamp":1532563200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aust J Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Few population\u2010based studies assess both invasive and <jats:italic>in\u00a0situ<\/jats:italic> melanoma. We document all patients with a first biopsied melanoma in a general population in New Zealand (<jats:styled-content style=\"fixed-case\">NZ<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All residents in a defined area of New Zealand with a biopsy showing a new primary invasive or <jats:italic>in\u00a0situ<\/jats:italic> melanoma from 2010 to 2012 were identified, 974 patients; analysis used multivariate methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Age\u2010standardised incidence rates were 34.3 in females (F) and 41.4 in males (M) for invasive, 20.9 F and 27.6 M for <jats:italic>in\u00a0situ<\/jats:italic>, and 55.2 F and 69.0 M for total melanoma. More <jats:italic>in\u00a0situ<\/jats:italic> melanoma occurred in older patients and on the head and neck. Geometric mean Breslow thickness for invasive was 0.78\u00a0mm F and 0.85\u00a0mm M, with thicker lesions at ages over 60 and on the lower limb; there was no significant relationship with sex, distance from care or social deprivation assessed from residential address. Nodular melanomas (15%) were more frequent in older and male patients, and on the limbs, and were thicker. The estimated cumulative risk for melanoma is 4.4% F and 4.6% M by age 70. The body site distribution and sex differences were consistent with sun exposure patterns. Estimated incidence of melanoma in New Zealand in 2018 is 2500 invasive and 1700 <jats:italic>in\u00a0situ<\/jats:italic> cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Assessing both <jats:italic>in\u00a0situ<\/jats:italic> and invasive melanoma expands the clinical picture, better estimating health care demand and costs. Results suggest that <jats:italic>in\u00a0situ<\/jats:italic> disease is a more slowly growing lesion than the early phase of invasive disease. The features of thicker or nodular melanoma show priorities for prevention and early detection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/ajd.12884","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T00:49:06Z","timestamp":1532652546000},"page":"38-44","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["<i>In situ<\/i> and invasive melanoma in a high\u2010risk, New Zealand, population: A population\u2010based study"],"prefix":"10.1111","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5730-4791","authenticated-orcid":false,"given":"J Mark","family":"Elwood","sequence":"first","affiliation":[{"name":"School of Population Health University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella J\u2010H","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Population Health University of Auckland Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken H\u2010K","family":"Ip","sequence":"additional","affiliation":[{"name":"Department of Medicine Middlemore Hospital Auckland New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Oakley","sequence":"additional","affiliation":[{"name":"Waikato Clinical Campus University of Auckland Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3393-6748","authenticated-orcid":false,"given":"Marius","family":"Rademaker","sequence":"additional","affiliation":[{"name":"Waikato Clinical Campus University of Auckland Hamilton New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15688"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.23.4799"},{"key":"e_1_2_6_4_1","unstructured":"SalmondC CramptonP AtkinsonJ.NZDep2006 Index of Deprivation. 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