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After exclusion of an inflammatory, infectious or neoplastic origin, a thorough personal history revealed that for many years the patient had been using analgesic suppositories containing indomethacin, caffeine, and prochlorperazine dimaleate, four to five times a week, for migraine. On stopping the suppositories, there was complete healing within 12\u00a0weeks. We hypothesize that vasoconstriction and vascular damage were the pathogenetic mechanisms behind the perianal ulcers.<\/jats:p>","DOI":"10.1111\/ajd.12888","type":"journal-article","created":{"date-parts":[[2018,7,24]],"date-time":"2018-07-24T21:10:09Z","timestamp":1532466609000},"page":"50-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Multiple perianal ulcers due to suppositories"],"prefix":"10.1111","volume":"60","author":[{"given":"Francesco","family":"Savoia","sequence":"first","affiliation":[{"name":"Unit of Dermatology Department of Experimental, Diagnostic and Specialty Medicine Sant'Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3026-2434","authenticated-orcid":false,"given":"Andrea","family":"Sechi","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Department of Experimental, Diagnostic and Specialty Medicine Sant'Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Tabanelli","sequence":"additional","affiliation":[{"name":"Unit of Dermatology AUSL della Romagna Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Zago","sequence":"additional","affiliation":[{"name":"Pathologic Anatomy Unit AUSL della Romagna Ravenna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Leuzzi","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Department of Experimental, Diagnostic and Specialty Medicine Sant'Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Baraldi","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Department of Experimental, Diagnostic and Specialty Medicine Sant'Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Patrizi","sequence":"additional","affiliation":[{"name":"Unit of Dermatology Department of Experimental, Diagnostic and Specialty Medicine Sant'Orsola\u2010Malpighi Hospital University of Bologna Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,7,24]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00105-014-3534-4"},{"key":"e_1_2_2_3_1","first-page":"39","article-title":"Perianal ulcers caused by ergotamine\u2010containing suppositories","volume":"5","author":"Baptista AP","year":"1992","journal-title":"Acta Med. 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